ID T1FMM0_HELRO Unreviewed; 292 AA.
AC T1FMM0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Tropomyosin {ECO:0008006|Google:ProtNLM};
GN Name=20210069 {ECO:0000313|EnsemblMetazoa:HelroP185286};
GN ORFNames=HELRODRAFT_185286 {ECO:0000313|EMBL:ESO10832.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185286, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10832.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185286}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction. {ECO:0000256|ARBA:ARBA00002987}.
CC -!- SIMILARITY: Belongs to the tropomyosin family.
CC {ECO:0000256|ARBA:ARBA00009036}.
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DR EMBL; AMQM01002757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095858; ESO10832.1; -; Genomic_DNA.
DR RefSeq; XP_009011101.1; XM_009012853.1.
DR AlphaFoldDB; T1FMM0; -.
DR STRING; 6412.T1FMM0; -.
DR EnsemblMetazoa; HelroT185286; HelroP185286; HelroG185286.
DR GeneID; 20210069; -.
DR KEGG; hro:HELRODRAFT_185286; -.
DR CTD; 20210069; -.
DR eggNOG; KOG1003; Eukaryota.
DR HOGENOM; CLU_055027_0_2_1; -.
DR InParanoid; T1FMM0; -.
DR OMA; EDEWAHE; -.
DR OrthoDB; 2917119at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 2.
DR Gene3D; 1.20.5.340; -; 1.
DR InterPro; IPR000533; Tropomyosin.
DR PANTHER; PTHR19269; TROPOMYOSIN; 1.
DR PANTHER; PTHR19269:SF45; TROPOMYOSIN-1, ISOFORMS 33_34; 1.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT COILED 72..155
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 184..281
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 292 AA; 33860 MW; 2E42DE6639906EC9 CRC64;
MANAAFNTMN AIKKKVHTMK TLKDSAGDEV ELLEQKLLEY KAIGEKNEEE LMNLNKRIFQ
IQNDQGITQQ QLSDALEKYN TINKNLSQAE AEMLNLSKRV RSIEEEYETV ENKLIQTTTK
WEQASKAFEE SQRGIKVLEA RIYTDEERIA QIETELEVII LFGEDADRKY EETARKLAIT
EVDLSRSESR VQIAEARGME LEEEYKVVSN NMKSLEIFQI EAQARFENYE MIVTSLTHQL
QETESRAASA ERMVTFLQKE IDKIEDELAA EKDKFRLVAN ELDFTFTELT AF
//
