ID T1FN96_HELRO Unreviewed; 681 AA.
AC T1FN96;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Heat shock 70 kDa protein cognate 5 {ECO:0008006|Google:ProtNLM};
GN Name=20210294 {ECO:0000313|EnsemblMetazoa:HelroP185768};
GN ORFNames=HELRODRAFT_185768 {ECO:0000313|EMBL:ESO00354.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185768, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00354.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185768}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; AMQM01005420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01005421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01005422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096945; ESO00354.1; -; Genomic_DNA.
DR RefSeq; XP_009021404.1; XM_009023156.1.
DR AlphaFoldDB; T1FN96; -.
DR STRING; 6412.T1FN96; -.
DR EnsemblMetazoa; HelroT185768; HelroP185768; HelroG185768.
DR GeneID; 20210294; -.
DR KEGG; hro:HELRODRAFT_185768; -.
DR CTD; 20210294; -.
DR eggNOG; KOG0102; Eukaryota.
DR HOGENOM; CLU_005965_2_1_1; -.
DR InParanoid; T1FN96; -.
DR OMA; MGTDWKI; -.
DR OrthoDB; 143at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR CDD; cd11733; HSPA9-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00332; DnaK; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012725; Chaperone_DnaK.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR NCBIfam; TIGR02350; prok_dnaK; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT REGION 654..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 297..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 658..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 74026 MW; 6B2AB23399BD8254 CRC64;
MLSITKISPF FAKTLNGGCS ATNVFKKLTP VCSINRLEAN KKRFISSEKI KGHVIGIDLG
TTNSCVAVME GKTPKVLENS EGARTTPSVV AFTNDGERLV GQPARRQAVT NSKNTLYATK
RLIGRRYDDP EIQKDMKNLS YKIVKASNGD AWLEAQGKVY SPSQIGAFVL TKMKETAENY
LGVTVKNAVI TVPAYFNDSQ RQATKDAGQI AGLNVLRVIN EPTAAALAYG MDKAEDKLIA
VYDLGGGTFD ISILEIQKGV FEVKSTNGDT LLGGEDFDNT LLKFLVDTFK KEQGIDIKKD
NMALQRLKEA AEKAKIELSS SLQTDINLPY LTMDSSGPKH MNMKLTRAKY ESLVDDLIKR
TVGPCQKALQ DADVKKSDIG EVLLVGGMTR MPKVQSVVQD LFGRTPSKSV NPDEAVAIGA
AIQGGVLAGD VTDVLLLDVT PLSLGIETLG GVFTKLINRN TTIPTKKSQV FSTAADGQTQ
VEIKVHQGER EMASDNKLLG QFQLIGIPPA PRGVPQIEVT FDIDANGIVH VSARDKGTGK
EQQIVIQSSG GLSKDEIENM VRNAEKHAEE DRRKKEVVEA VNSAEGIIHD TESKMDEFKA
QLPSDECKKL NEQIAKVRQM LSNKDQETPE NIKKATSDLQ QASLKLFEMA YKKMAAERES
SPSSSSSSSS AGKDDDKSLT L
//
