ID T1FNF9_HELRO Unreviewed; 210 AA.
AC T1FNF9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=DNA replication complex GINS protein PSF3 {ECO:0000256|RuleBase:RU367161};
GN Name=20210356 {ECO:0000313|EnsemblMetazoa:HelroP185921};
GN ORFNames=HELRODRAFT_185921 {ECO:0000313|EMBL:ESN97202.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185921, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN97202.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185921}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. {ECO:0000256|RuleBase:RU367161}.
CC -!- SUBUNIT: Component of the GINS complex.
CC {ECO:0000256|RuleBase:RU367161}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367161}.
CC -!- SIMILARITY: Belongs to the GINS3/PSF3 family.
CC {ECO:0000256|ARBA:ARBA00006343, ECO:0000256|RuleBase:RU367161}.
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DR EMBL; AMQM01006392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097417; ESN97202.1; -; Genomic_DNA.
DR RefSeq; XP_009024697.1; XM_009026449.1.
DR AlphaFoldDB; T1FNF9; -.
DR STRING; 6412.T1FNF9; -.
DR EnsemblMetazoa; HelroT185921; HelroP185921; HelroG185921.
DR GeneID; 20210356; -.
DR KEGG; hro:HELRODRAFT_185921; -.
DR CTD; 20210356; -.
DR eggNOG; KOG1106; Eukaryota.
DR HOGENOM; CLU_081646_2_0_1; -.
DR InParanoid; T1FNF9; -.
DR OMA; IYKEGWR; -.
DR OrthoDB; 3670282at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IBA:GO_Central.
DR CDD; cd11713; GINS_A_psf3; 1.
DR CDD; cd21693; GINS_B_Psf3; 1.
DR Gene3D; 1.20.58.2050; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR010492; GINS_Psf3.
DR InterPro; IPR038437; GINS_Psf3_sf.
DR PANTHER; PTHR22768:SF0; DNA REPLICATION COMPLEX GINS PROTEIN PSF3; 1.
DR PANTHER; PTHR22768; UNCHARACTERIZED; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367161};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 60..166
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
SQ SEQUENCE 210 AA; 24635 MW; BB1025BD779F0D81 CRC64;
MSLYLDLYSF ENFNENYFKI DDILATQERL VCRFETEIPN MGYLDTSSDS TNILPGTKLE
LPLWLVLPLS TRQRQYATVD LPKQYGSAYR EIFSADASVV DLHKLGPHYY RLGLQLVNCC
YLEAVDICKS LLTTFQKRLC RIIDTSLNSS EQDANKFKEI LDQVERCLYR CGQKCTQEFL
KWQSREIEKI TSSDMVVNIR KRKRYQMENS
//
