ID T1FNJ0_HELRO Unreviewed; 399 AA.
AC T1FNJ0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN95245.1, ECO:0000313|EnsemblMetazoa:HelroP185992};
GN Name=20210387 {ECO:0000313|EnsemblMetazoa:HelroP185992};
GN ORFNames=HELRODRAFT_185992 {ECO:0000313|EMBL:ESN95245.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185992, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN95245.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185992}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC {ECO:0000256|ARBA:ARBA00007601}.
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DR EMBL; AMQM01006884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097536; ESN95245.1; -; Genomic_DNA.
DR RefSeq; XP_009026648.1; XM_009028400.1.
DR AlphaFoldDB; T1FNJ0; -.
DR STRING; 6412.T1FNJ0; -.
DR EnsemblMetazoa; HelroT185992; HelroP185992; HelroG185992.
DR GeneID; 20210387; -.
DR KEGG; hro:HELRODRAFT_185992; -.
DR CTD; 20210387; -.
DR eggNOG; KOG0774; Eukaryota.
DR HOGENOM; CLU_041153_1_0_1; -.
DR InParanoid; T1FNJ0; -.
DR OMA; ANMYNAK; -.
DR OrthoDB; 3684468at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005542; PBX_PBC_dom.
DR PANTHER; PTHR11850:SF108; HOMEOBOX PROTEIN EXTRADENTICLE; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 44..228
FT /note="PBC"
FT /evidence="ECO:0000259|PROSITE:PS51978"
FT DOMAIN 227..290
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 229..291
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 304..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 45026 MW; 2A48C74008072119 CRC64;
MMDDGMAYGM QGQMMLQPQS YPAIHGNQQV MMESCGMMGD DMGGGKRAIG DILQQIMNIT
DQSLDEAQAR KHTLNCHRMK PALFQILCEI KEKTVLSIRN CQDDDPPDAQ LMRLDNMLIA
EGVAGPEKVG GSMVAPSENA IEHADYRAKL IQIRQIYNSE LEKYEQACSE FTSHVVNLLH
EQSRTRPIAP KEIDRMVSII RKKFTAIELQ LKQSTCEAVM ILRSRFLDAR RKRRNFSKQA
TEMLNEYFYS HLSNPYPSEE AKEELARKCG ITVSQVSNWF GNKRIRFKKN VGKGQEEANM
YNAKMAGSGT NNNGSSNNAN SNYNSNNFNN NSSDSKSPML PKLESADSQC LSDSQESWGT
PAYSMPTRPD LYMSMNPNMG YTDILPTSTS NMYDPHIRQ
//
