ID T1FNR0_HELRO Unreviewed; 400 AA.
AC T1FNR0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Snurportin-1 {ECO:0000256|ARBA:ARBA00016034};
GN Name=20210457 {ECO:0000313|EnsemblMetazoa:HelroP186161};
GN ORFNames=HELRODRAFT_186161 {ECO:0000313|EMBL:ESN92097.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP186161, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92097.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP186161}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC {ECO:0000256|ARBA:ARBA00003975}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the snurportin family.
CC {ECO:0000256|ARBA:ARBA00007540}.
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DR EMBL; AMQM01007782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097667; ESN92097.1; -; Genomic_DNA.
DR RefSeq; XP_009029755.1; XM_009031507.1.
DR AlphaFoldDB; T1FNR0; -.
DR STRING; 6412.T1FNR0; -.
DR EnsemblMetazoa; HelroT186161; HelroP186161; HelroG186161.
DR GeneID; 20210457; -.
DR KEGG; hro:HELRODRAFT_186161; -.
DR CTD; 20210457; -.
DR eggNOG; KOG3132; Eukaryota.
DR HOGENOM; CLU_056809_0_0_1; -.
DR InParanoid; T1FNR0; -.
DR OMA; NIEHRHT; -.
DR OrthoDB; 197726at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
DR CDD; cd09232; Snurportin-1_C; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR InterPro; IPR017336; Snurportin-1.
DR InterPro; IPR024721; Snurportin-1_N.
DR InterPro; IPR047857; Snurportin1_C.
DR PANTHER; PTHR13403:SF6; SNURPORTIN-1; 1.
DR PANTHER; PTHR13403; SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1; 1.
DR Pfam; PF11538; Snurportin1; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 26..68
FT /note="Snurportin-1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11538"
FT REGION 363..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 45968 MW; 259643A07C90001D CRC64;
MEELEASLAL NFNVSGDPNS SLSTVHPRLS VYKNYARHDP ERSQEKRRKE IMKTMKEKRS
NVVERLRNLT SDGFGEDEVV GCHADLDFPP TVVAPPVHIS GDLEKDKVVS GRNVAAAAKR
LKDQLMLSEW MIDVPEDFED DWYMLKCPVG KRCLVVASQG TTKVFRRNGH LLIEFQSNLC
GGSRADLNRK HNAILDCVFS NMKQFYVLDM MVINNMQLYN VDTECRWFIM ESKFREELHE
ATVQSNFNPY PFVLCDRTYS CRKEVLEQLM AVESEEYDLD GLLFYHKKAD YLIGTTPFQL
WLVACMLPDF LGVKVADSYI RKKPLWYKSK LQHVKRVENN KTRVYRTCDR LTSAMGAARI
ADASAGDNSN NNDNNNNNNN NNNDDDDNNN NNDNNDINMN
//
