ID T1FP46_HELRO Unreviewed; 355 AA.
AC T1FP46;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Cyclin-like domain-containing protein {ECO:0000259|SMART:SM00385};
GN Name=20210593 {ECO:0000313|EnsemblMetazoa:HelroP186943};
GN ORFNames=HELRODRAFT_186943 {ECO:0000313|EMBL:ESO05672.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP186943, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05672.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP186943}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01003849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01003850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096325; ESO05672.1; -; Genomic_DNA.
DR RefSeq; XP_009016305.1; XM_009018057.1.
DR AlphaFoldDB; T1FP46; -.
DR STRING; 6412.T1FP46; -.
DR EnsemblMetazoa; HelroT186943; HelroP186943; HelroG186943.
DR GeneID; 20210593; -.
DR KEGG; hro:HELRODRAFT_186943; -.
DR CTD; 20210593; -.
DR eggNOG; KOG1675; Eukaryota.
DR HOGENOM; CLU_055026_0_0_1; -.
DR InParanoid; T1FP46; -.
DR OMA; DECPITT; -.
DR OrthoDB; 5476605at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR CDD; cd20540; CYCLIN_CCNY_like; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR012399; Cyclin_Y.
DR PANTHER; PTHR14248; CYCLIN Y, ISOFORM A; 1.
DR PANTHER; PTHR14248:SF18; CYCLIN Y, ISOFORM A; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF028934; Cyclin_CG14939; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 1.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 200..285
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..112
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 41381 MW; EFE276511836F6AB CRC64;
MGNCCMSKEP QNSFQNESFN NNSQNVLNHH HINVQQVVSA SKESINYKSS SSNLQHINDR
EPEESVNDPS VHPQACPIFL MRSVSDKHRK STDHRRRKSQ YDNHHHHHHH REYGRIIRKF
SSCSTIFIDD STVSQPNLKN TIRAVALAIY FHIRNRVQRD PAAFEDSQMD IFDETKYPMS
KEALPEDHFR RDPEHKTIYK FIRNLFHSAQ LTAECAIVTL VYLERLLTYG DMEMLPKTWK
RIVLGAILLA SKVWDDQAVW NVDYCQILKE ITVENMNELE RQFLELLQFN INVSSSVYAK
YYFDLRALAE AHDLTLPFEP LSKERAIKLE VSNALKRRHS DGFASNPRLS KAIIS
//
