ID T1FPX4_HELRO Unreviewed; 868 AA.
AC T1FPX4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=PDZ domain-containing protein {ECO:0000259|PROSITE:PS50106};
GN Name=20210871 {ECO:0000313|EnsemblMetazoa:HelroP188365};
GN ORFNames=HELRODRAFT_188365 {ECO:0000313|EMBL:ESO06466.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP188365, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO06466.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP188365}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096324; ESO06466.1; -; Genomic_DNA.
DR RefSeq; XP_009015834.1; XM_009017586.1.
DR AlphaFoldDB; T1FPX4; -.
DR EnsemblMetazoa; HelroT188365; HelroP188365; HelroG188365.
DR GeneID; 20210871; -.
DR KEGG; hro:HELRODRAFT_188365; -.
DR CTD; 20210871; -.
DR eggNOG; KOG3209; Eukaryota.
DR HOGENOM; CLU_004562_2_0_1; -.
DR InParanoid; T1FPX4; -.
DR OMA; XYRSEVK; -.
DR OrthoDB; 2902917at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 5.
DR Gene3D; 2.30.42.10; -; 5.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR10316:SF40; LD27118P; 1.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR Pfam; PF00595; PDZ; 5.
DR SMART; SM00228; PDZ; 5.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR PROSITE; PS50106; PDZ; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 94..166
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 271..333
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 561..643
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 664..747
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 777..860
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 95680 MW; E29864C9867537A5 CRC64;
MAAQQKRAYS TTPTTNDPNH EISVVTNANS ISSDLYNNYI NNNSSNSLNN NQLMNSSNQT
NNEILAINQQ QMHQHRQQQL LLPQPQQPLQ QLITTMLKKT SRGLGFTIRG LEDEDGGGVW
LVIKSILPAG PAEMDGKLQR GDVLVSVNDH DVCGLTHFDV VNMFRQLEIN QEVKIEVIRG
HHSTLNFDLY DGEVNDPSVE VLTTVAVGNA DGDDSESSYY SEDVGNARVV YDYHKCMTYN
NGSIFSGGPQ DIGGVCPYYE YQGLVGVKKI ELIIVKGPTG FGFTLADRPE GQKVKQLVDM
NRCRGLSEDD LLLEINNQSI RNFSHLEVVQ MLKLCPTNQP ALFLVERKVL QSKCLNVNDV
NSSSISSLQL CTLNGGSCMP NSPYYFRPYS AGSQMQHQQH FLTNSKQLMK HQEHNLYLPL
QKEYESNNRS FKQSPCMVHE HLRKQLSSPS SASTLIIDSL TYPQQTPDFI PANVFTSSST
SSESKLTANE SGYVGSVSST SKPQTYRYCS AVEPHNLHHC FNEFCSSCYA DNLYLDSINN
NNNIVNANIN AGANNNMVIK TVFLKKSPTG FGFRVVGGKE EGSQATIGHI VPGGPAYLDG
NLCVGQEIVL IDGLNVEGAW HKDVVDLINM AAQKGEVMLS VRDPTDFLNN NQMESMHLSQ
QLHDVVLTRN ENEGFGFYIL SSAIKSSPVI GQIVENSPAS RAANLKIGSQ IIAINNNLIL
NNMSHNQIVD IIKSSGTSIK LTLTDATPSA PSIDRMIMQA TEFKNEGTAD SEVAIIDIDL
HRSNKGFGFS IRGGQEFNLM PLYVLKIADD GAAKLDGRLQ VGDEILKIND AMTQGMTHRD
AINIVQSTQA VLHLTIRRFA NLSEADDL
//
