ID T1FQB3_HELRO Unreviewed; 491 AA.
AC T1FQB3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20211010 {ECO:0000313|EnsemblMetazoa:HelroP188735};
GN ORFNames=HELRODRAFT_188735 {ECO:0000313|EMBL:ESO02519.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP188735, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02519.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP188735}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02519.1; -; Genomic_DNA.
DR RefSeq; XP_009019927.1; XM_009021679.1.
DR AlphaFoldDB; T1FQB3; -.
DR STRING; 6412.T1FQB3; -.
DR EnsemblMetazoa; HelroT188735; HelroP188735; HelroG188735.
DR GeneID; 20211010; -.
DR KEGG; hro:HELRODRAFT_188735; -.
DR CTD; 20211010; -.
DR eggNOG; ENOG502QV76; Eukaryota.
DR HOGENOM; CLU_031820_1_0_1; -.
DR InParanoid; T1FQB3; -.
DR OMA; QFTGTKG; -.
DR OrthoDB; 5406876at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd01765; FERM_F0_F1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF13; E3 UBIQUITIN-PROTEIN LIGASE MYLIP; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 8..295
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 428..463
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 350..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 56148 MW; 17DB3E8EC761EBF8 CRC64;
MPRSSDVVCI IVTMPNSYDF VVEAPRSASG YFVFDKVCDK LKLLQKDFFG LQMIDEENNK
RWLNLRNLIV SEVGSSQFFR FLFGIKFFVQ THYLLQERTR EIFFQLAKNQ IIETEGPPML
SESLLNTSLT ILAQYYNSSN SKHSNLEDDD TTYETVLQKL SSSSKATDNS SSKLLFNDLL
REASRNEIRT LFLRNMSHYM NAIGHKYTAE LDREVVVIGV LPGGISFLSN CLEPLRSYPW
CSLQQATQNA LEVTVKVISD DLSIKPLKFM LHNKSSANAF YRDLTEVYTF FHCDSVAEPV
MQQFCRDFKG TFAALFVENS DYGKEYIFDI EHTLKESDDR IRRHIYKEEK NKLSENNNNN
NNNNNNNNSN IDSCSRSSNC ITSVEYKLPS DFDKENANTI DGNCAGVSCR ADCPSADKLK
SVRDSFLCCI CADREIGTAL DPCGHAFTCY KCSDRIDSCP ICKRDVLKVI RLYLPHSFYN
RADDQILPYV S
//