ID T1FQI7_HELRO Unreviewed; 1826 AA.
AC T1FQI7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20211084 {ECO:0000313|EnsemblMetazoa:HelroP188971};
GN ORFNames=HELRODRAFT_188971 {ECO:0000313|EMBL:ESN98985.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP188971, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98985.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP188971}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097143; ESN98985.1; -; Genomic_DNA.
DR RefSeq; XP_009022904.1; XM_009024656.1.
DR STRING; 6412.T1FQI7; -.
DR EnsemblMetazoa; HelroT188971; HelroP188971; HelroG188971.
DR GeneID; 20211084; -.
DR KEGG; hro:HELRODRAFT_188971; -.
DR CTD; 20211084; -.
DR eggNOG; KOG1428; Eukaryota.
DR HOGENOM; CLU_000562_1_0_1; -.
DR InParanoid; T1FQI7; -.
DR OMA; EYCNSSH; -.
DR OrthoDB; 167377at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0008582; P:regulation of synaptic assembly at neuromuscular junction; IBA:GO_Central.
DR CDD; cd19799; Bbox2_MYCBP2; 1.
DR CDD; cd16463; RING-H2_PHR; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45943; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR PANTHER; PTHR45943:SF1; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 893..1071
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1572..1623
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 125..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1826 AA; 205222 MW; 4281CE2356113292 CRC64;
MARIFDNIFI KVRNDKKFKE DEIVLSNRDN NNKVMDVVAV KKLIHKTGDN LFNGNGNAPP
PTPKKSIPVK KPFNDTLIED QNNLNVLPFM DYATSEPPSF HYNDALLNQR LIKLATDSNY
RSISFSPPRT STTSATYSRS SSLPVGSHRC NGGDHKRNQA NKKIVSSYMV QRNFKYFKFQ
QTSDGKLTSA SSSLPTMCHA ISPSVAECIR SMFAVFLWKE DIVQDAMACA SFLKFHPSFT
KEHCLDGIES NNLKTGETKN ILYEDDQVYG GGAEGVEELS NDVDSVLTEK SSSNESNINN
NNINAIYINV TNNNNNDNSN NNIICSNSNN NNNNDGIDLN AAKTFVKMLS PKLPTLKHLV
KIWQDISKAT LKMIENSSYL SAKSSNEIDL NYKLPSPASK SSKHNLLNES KSLDKSEKEI
ACDLCGVVCS NPITYHMRQN HPGCGKSAGG QGYNSGGLFC EGWAGNCGDG GLGTSTWYLI
CESCRSRYQT NWQASSHLNN SKHSKPVFEC KKEFAYISDY HNVIKNNATF IMDFFNYNSS
SSFNKSEAEV ENMTSPYQFP PTPFSYINLH DMATTETDLS NQDIVTGEFS YRIGRKPMNS
SITTQISATN HQSSCRSRPK SVYGEYKFEA GNMSATSYNL SKHANLTPDN QTFQRFHRSI
SEMGPAIGMG IKSVESSSSK NILLKKTSRG LSLLNHPSYQ MTCLIQATEK EMQSNKISVS
EYLMCQPLMQ FCTQIHDLEC LKKGMKLATC KVACRVHALQ AFNWFFRQVS ELSSIHDLLW
HFVSTLALYS DEDKDCLSRM KYLNKETDSD CNEIICQHPL TDVVFVKTHS NLILDSFYSF
LQSLSDVMML IPHGSPVQLM AIRSWFFKFE PIDHDFLHQC NVFNSISKIL SNSEVVHKSL
LNTSCAPFNY ITQLKDITSF AEIITSSHPQ MVVSLTDQCT ETFWESGDED RNKSKLITLS
LSKDQNPMLL CIHIDNVRDL NNKVTSVVVS SGTNQEDLYV DKHVEIELRF AGWISVWFTK
ESTNFIKLEL KGPDNSLRVR QIKLLECPFY KHFIELPSGI FNEVLQYALC EKETLNVFKF
LTSQVFGSLV TSEELVTSEE HSSNNTANLK EHMVGILFSQ RKLTNMQKQV CTYMLQAIQK
ETVDVYNKWN NLQDKCVNAK EHSDKYCFEL LSLLMALTGS KVGCLFVAQQ NSLLKDLLTL
LHTSTARVQR QVVLLLRRLL VYVDPIKFSE ILGLNFENDV EEDAVGILDI FLSCIAKSIT
IQIKQSKTAG ASSADTCTLA DNRLHKLNLK CWWLKGSSSV QLAELIISFL TDLSEGKITK
FWSSVTKSAI RDNILKLSRL HDERRYPNAC VQTICFWMTL ASLCILNKDD AEKLSTSTDA
KVGSEKTKNI SCENHDDGET YAIMNCSICG NLCSECNRVL HLSKKTKDHQ RQIFKEERES
IKVDCHEICG RIKLFWLLAL VDTKNLKAII EFRGIDNHNI SSDSLNLVFT KKNEFCRFCG
SPCENGIEDK IAGMSCNQPD CMNLYSKACI KVLSCGHMCG GIKNEEKCLP CLYGCKSSDT
SISLKQDADD MCMICFSDAL SRAPAIQLSC GHVFHLPCCE KVLVSKWPGP RITFNFFLCP
ICKTEMNHPA LNELLTPIKN RYEDVRRKAL MRLEYEGLHC SNSIVAQGSA YFNDPAGYAL
NRYAYYVCSK CDKAYYGGEA RCEEQVVGGA NGFEDYDASE LVCGACSDVS RAQICPKHGA
DFLEYKCRYC CSVAVFFCFG TTHFCNVCHD DFQRITSISV NELPHCPAGS KARQLEGNQC
PLNIIHPATG TEFALGCGIC RNAHTF
//