ID T1FQX6_HELRO Unreviewed; 744 AA.
AC T1FQX6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Tetraspanin {ECO:0008006|Google:ProtNLM};
GN Name=20211223 {ECO:0000313|EnsemblMetazoa:HelroP189297};
GN ORFNames=HELRODRAFT_189297 {ECO:0000313|EMBL:ESN96580.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189297, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96580.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189297}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMQM01001414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96580.1; -; Genomic_DNA.
DR RefSeq; XP_009025725.1; XM_009027477.1.
DR AlphaFoldDB; T1FQX6; -.
DR EnsemblMetazoa; HelroT189297; HelroP189297; HelroG189297.
DR GeneID; 20211223; -.
DR KEGG; hro:HELRODRAFT_189297; -.
DR CTD; 20211223; -.
DR HOGENOM; CLU_373517_0_0_1; -.
DR InParanoid; T1FQX6; -.
DR OrthoDB; 5360635at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03127; tetraspanin_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 2.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282:SF560; RE08073P-RELATED; 1.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR Pfam; PF00335; Tetraspanin; 2.
DR SUPFAM; SSF48652; Tetraspanin; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 81704 MW; 3089E56B500397AA CRC64;
MVLATLNGPQ EEETEKSEAA QKTKGPEAEG GVSFFVSFTN SKRGRERRTR PRRPRVDVRN
RVGRIPVGAQ RGKSKEEGEA GEDDGKEKED GDKKISEMRN ANAVLAAKPQ PLPPYLKVEQ
QEIDDAAWEE ANAAASALFR CLLLVISAIL MITCIFNLLA GSAIKIGGEA MFIKEASTYG
NYLIFLGVMH FVTFVLGFFG ALLKKSFLVL LFMFSVVLLL MFNLIGAAIV FSGLSNAHVD
PAAGFMKEIA KRDYKSFIND FQKAQSCCGA HTAFDWRANP DYQDGLLLPA SCCPSTEGPC
SAESKEYFSQ GCREAFNHML IKYGKMHAWV SIVAGICEFL CMSVDRCTET DRTTAKYNSD
SIRIPISPTT LENDKVQHTI SRSLIAINPS RESWKGDPPS KQVDYREKTS PVDAKISVSL
HSLHIHAASK EAAANDNEIQ ILPYKTFEEE DENLPVSSGK SRKEGERLKK EKVISVFDVV
KTLYKQQRIK PPKTPNHGQT DDPTQQSSIA SLRQALRHAF SSAVISKYQQ DVMEKVEARS
PKLSLNDSAS ISTKSNDSYP SPPLIISMVP IYILTLIVIL LGMFRVSLGT VAGISLKALD
ASEGDMVVAM TCVSGLFNLV VGVVAYVAAF KASLILFIML SFVVSNSIIL VIVSSSLVYI
SVQECKSNST WLLLQSISNA ETAVNVELLQ ILFKCCGANS HDDWLLNANH TNGTLPSSCC
LPYGSKNCNA NSKNIYEVEE EIIK
//