ID T1FRJ1_HELRO Unreviewed; 777 AA.
AC T1FRJ1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20211438 {ECO:0000313|EnsemblMetazoa:HelroP189957};
GN ORFNames=HELRODRAFT_189957 {ECO:0000313|EMBL:ESN90707.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189957, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN90707.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189957}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; AMQM01002368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01002369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097753; ESN90707.1; -; Genomic_DNA.
DR RefSeq; XP_009031590.1; XM_009033342.1.
DR AlphaFoldDB; T1FRJ1; -.
DR STRING; 6412.T1FRJ1; -.
DR EnsemblMetazoa; HelroT189957; HelroP189957; HelroG189957.
DR GeneID; 20211438; -.
DR KEGG; hro:HELRODRAFT_189957; -.
DR CTD; 20211438; -.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_006105_4_0_1; -.
DR InParanoid; T1FRJ1; -.
DR OMA; CARIFNG; -.
DR OrthoDB; 2876738at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IBA:GO_Central.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF200; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..777
FT /note="Peptidase S9 prolyl oligopeptidase catalytic domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010980926"
FT DOMAIN 97..414
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 536..733
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 413..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 89425 MW; A3A8F61426ADBFEB CRC64;
MSGITVLTLL TMGLLVSNTK SIFEFNDIYD PTFRPKSFNP TWISEEEFYY TNKSNDIVLF
NAKNRNVSEV ILANKTRPEG VEFLLMAPDP LYYKTHFVYG KDYKKNWRHS YSAIYYIFDK
NGNKTYHLPK NDTEGNMRLD FVTWAPKEER WSYVYRNNLY YQAGVDGTVR QITHTDNVKE
PFKYNGIPNW LYEEDVLSSR VAQYWSPDAK YLCYATIVDD PNYTQQWPIF KNHSYVYEDW
VKITYPKAGF KDHAGKVVST SNVTLHVFFE DPNAKGKIIT LKPPKNLIGE YHYYLQVVWK
TETEVFVTWT NRKQSIQYDV IYDVAKEGEP KWEVQFEEQT KGWIEVPPAR PVFLDGKPGY
FTIQPIYNSE KKQTWRHIVH VDPTIAPGDQ ITDMMPGKQM TVDSVVGIDN KNDILSTNHA
DNNNNHNANN NTNNNHNNNH NNNNNTNNNH NNNNNHNAND NTKNNQRPAT ASDVCLTCNN
NDCKYFGANF GPNARHYFRN CLGPDVPKYT LVGSNTTQEV SKRFEMGSRT KNWLQHLASK
YRIAVASIDG RGTLGQGEEL KFKIYKKLGV VEVEDQIKGV SHMMKESEFV DDKKPAAIFG
WSYGGHTAAH VLAQNNTHFN CAISIAAVTS KGFYDTAYSE RYLGLVTEEN GTMAYENTNV
VKKAKQFKGK NFFIAHGLAD DNVHYTNFAQ FIKELEMNDV DFTQITYPDQ DHSITDEHLS
RHLYRSMTKF LVDDCFQLPS SGGMATLHFS TIMTSLITHY LYNLSMPMNA VYVTSSE
//