ID T1FRK4_HELRO Unreviewed; 3543 AA.
AC T1FRK4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Pericentrin/AKAP-450 centrosomal targeting domain-containing protein {ECO:0000259|Pfam:PF10495};
GN Name=20211451 {ECO:0000313|EnsemblMetazoa:HelroP189990};
GN ORFNames=HELRODRAFT_189990 {ECO:0000313|EMBL:ESO11529.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189990, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO11529.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189990}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; AMQM01002442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095812; ESO11529.1; -; Genomic_DNA.
DR RefSeq; XP_009010017.1; XM_009011769.1.
DR EnsemblMetazoa; HelroT189990; HelroP189990; HelroG189990.
DR GeneID; 20211451; -.
DR KEGG; hro:HELRODRAFT_189990; -.
DR CTD; 20211451; -.
DR eggNOG; ENOG502QV16; Eukaryota.
DR HOGENOM; CLU_224724_0_0_1; -.
DR InParanoid; T1FRK4; -.
DR OMA; MAQCEQA; -.
DR OrthoDB; 3030508at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProt.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR PANTHER; PTHR44981:SF2; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 3200..3251
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 18..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1854..1881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3382..3443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1060..1087
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1545..1650
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1674..1854
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1883..1931
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2283..2356
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2383..2572
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2613..2665
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2734..2941
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 93..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..346
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..436
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..520
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..630
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..668
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..763
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..897
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3543 AA; 402484 MW; 46580860B203EE0E CRC64;
MVPSTEEVDY LRECLKESTT LHSSGGTLVD SDLSQTPTHQ QPQLPLQPHQ LQPQLPHQLQ
PQLPQQQPPQ QQSSQQPELD QQHQFIYPQT FDQHQCEQQN PSHQRQNPQD QQQQSLLTPD
QMSDTFEPPQ PQQPPQPQQP QQPQQPQQPH LPQQPQQPQQ LQPQQPQKCL NCLAKDEQLK
IQSDMILHLK SKLESYEKEP SNIVAVVAND TDLNLKVKLE ELNDVIRVRD LEIDRLNALV
NELNSKIARI KNNLLNNKFK PSRGGEVDDD GGEDGGDNDG YGVSYDSQIK EYAQRLSIIE
ESDNDDDSGD DNADDDVNNG DDNDVNNDDD NDVNNDDDDD NNDDDDNVVN NLIVFDMGDE
VGDDDDDKNS DRDTGKKKVN DVVDDIADGD RDDDRDDDRD DDRDDDRDND RDDDRDDDRD
NDRDDDRDDD RDDDNPEIND DKIAKNNVDD GDGDKNDDDL DDNSGKNLSV LEEILSVHGN
DLLTDKLSDE QDPTITSDDD DDEDGDAICD IDEDDDDDGD DRKTDASRGV TEFGNSRDNA
DDGDDDDGGD IANDDKDDDN KENKDDINVS YKKRVSVELI KLSEENNLKM QRLMDKTDYT
HAHDENDEDD DDDDDDVGDD DDDDNDESKK VEDDENTNNN NNAKSNSDDG EDNDDDEDDD
DDDDGEEEPF LKSDRWERLF EDHTSKAAAH TNMSLDFKDE DDDDDVTNDM SHADNEVDSG
DLITTNNNVA NEVDLMITND LVEIGNNDDD KGDENDNDDD DDDEASVLSK HILDQLINDV
TDSVVIKEDD DDEDDVASNI ITVDDDGGHC KNDKKDGVLS DDFSGDDVAI ATARDEIDDD
EGDDAKKRNA RFLYDEALSL DDDDGEVDDE NTNDGEGDVD DEEEDDDEEE GNDIDDDNSK
TLDEKFFKEY KADEDDDVKP PIRDDVIGDN HITKYTEMVA EAVEITSLSS VISSVLIGYD
LKITPDNIDL IKEQVKTIAK HIISHDNAER MKLNDDEEEK EEDEDKTKIT KNDNDNGDKV
VTKTDHFLAH DNKYITSRRD INDEADDSDD DDDRGNKEKL RKSLKLVDEL QKEIKELKER
LNESSDVILA GDNDAAATAT TTTTAAAATA ATAATAATTT TTTNYNDDDN ADDDGDEIKK
LKTSLSSPLD RRVFEDEMRK KIEMIDILQE KVKGQEKLIM TLTDNNVNSN NDDNIDADDI
SINDELTATN NHIISTSALD DDNINNINDN VNLTMPDGDN NNDMNENNTN NNTNDDVIDD
IINSKDSIIV DDDENVNVTH ANNSDSISKQ PFNDTLDLMN DTKLKKESLT VTNELLHRIL
SESVRVSLES EKTVAEFFNR YKIFTKSINN YNNNNNNNNT NTNNNNNNNN SSNSNDDDGS
ETRVEDLNND NSKINNGNGS VATENYQLQQ QRFSCLPSQQ QGCSEFESFI RQSLDGNFSE
AGSLLSILYD DYNNKNNNDD DINNSTSGKS HQQPPADLTE RLINSILSDR CCNGDSDDGH
VHGDHVADED DDDDGDVTSH HKCGEVLTNS VLRLQTAITY MIGYIEECDS KYQQTAQQLE
KLIEDLDVAK AEKEHLNVNL SMKGRTLIDG LTLEKLALER TIAALEEKHE KLVRSSELVE
IELESYKRCH EDLELKQKEL EKNREIILNE TADFATQELL RENMKLSDDC RDMSRRLSRD
KQLFEMQLKE LEAANEQLSK QVEKLKEEGE VAARDAKMRM DALEKQLKSD KKFIEARDQT
NEREEEAELF QRRIKMMEDA LRDSEKLSSN HQRMKKEIES LEEQLKEKID GYANVLNLKE
VVELDLNQQI GTVAELRECI RALENELSEK CRREQELSLQ LEEMKIEKER YQSNVNAGNK
HSPADDSDDD DVNDGDASKD DEIHHLKEII DSLEKELKTS KAAEISLKAE MGKVKEDLKI
VESKMQDLKM DHEILGKQSV EQLIQLSNLK HLAEERCLDK YGRALASAGG GGGVSNNVVV
NGGSGDLDLK KMIEEKDKQI NDLTSRLTDT TQKHVHDKEM MDRLMDEVNE QKLNHTRMTE
LNKKLSDQTV ILKFKNEELS KTIDTLKLAT TSSTATTTTK SSPNESSMML LNEALIDEKN
DCIDELSAEV ESLRSQSRCR SLQTTTTSSA TTANNINNSA ALSYNTPEIL RKSDNSTSVS
QLQHIGISHH LGFSTDNLGI SKDGIAFSAD KFSQVHFENS LKAKAMMDDN NEETVLMVVD
DDDDGGDEQI VGRRRNEGRS GIGENGMVED LGEMLSPIND DYTHNSDMPI TQEDLSRYNV
NTFTELANMI EDKESTIKRL NQQLDQQISE NQSLNLVIDE LKLKLEQTIS SSDLELRKLK
DMLKVKETEL NDVIERLSHV VDQRTSDELD ATRLSVAQLE HVIEVKDDQI RSLTDGVERL
RRELDESTLN VEKLSTTITT KNLDLLNQEE INQKLQQVNK DLLQKNDNLT SHIETLENSV
NNTEKLLENS QKLLNDLQKR HETSTDLLRN KRTELEQMKD TCNQILAERN DLKIKLDNLE
VKLAGVEQQS KENVENVIQQ NAERLQQMNA SLISKENELQ TYLTQIEHLR EQLLESADKY
DDVCLSLDRL GSDRKTEIEA LKLIHESNVM ELSETHEQQI DKFMQQVQDL QQQLQHLQQQ
LQHQQQLQQQ QQQQQQQQQQ QLQKNKSSTN IRDVVDAEEE ALLSVLSHNN TLTTANTTTT
TTFDELLSED LLSILRKLHS EAMRVLSLSD CQFLESLEKK SIEMEELKER WMTEMERMKE
EKKVLEERLK IEEEVSTLKM ERLSRKYKDA RTLVEKLKAD LNGCKTVAQV SIAPSQQQQQ
WQQQTFQQER DKLVEERNRL QDDLVNLKAS IDVERSQNLE FGKKIERLLE DRTKMKSDMK
KMFDLLEVYE SEKSNLTQEL ASLQQQLSNS NQQKDSLQKQ LDDIKVKLDN IEQQIKQADR
KTSYSAAVAS AAAPSSLMSS DKLFLMKQLE LLRQKLQLYQ ILTRDKMFVC STLFGVALGV
QMSMECAGLL NDVLTDFTRT INNLELTSTA AVANYDIEML NDKILLHNNQ LTQHIQRFCN
TNSNDVGDIN NNIGNVNNNI GNINNDVIGG NSNTLHLNKH PQEAHGNMNT DNRMLIDEND
DDDDDDGVVM TSFARHSDVG LKVNSNAYNE LHGPVVADRK KQTSLHLDYG ADVEQHTQLN
NNEIHMRVTL TQQIQRLYGK YLRSESHRKS LIFQKNYLLT IISGYKHAEL DTINSIHHIT
NLARHHHQQH PHHRHHSNFN IASNGDISNS SVCSLVGSDP GDVDGVMAVD LNVNDSGINR
TLIRCRRSWV RGQSLSLMSK FRSAAWAVVA ILRLKFLVLK WQKATSWTRP MIATSQTTSQ
PTTTSSAAGN LKHQYSLQYL PQQHQQPRHQ QQQQQSLHQR QSQSTKSLSH EVRSARSLTT
LNNNNNNNIN NNRQQRKQLQ QQFQHTLPTS SYGYISDINI NDNNNNNTNN NINVNNNNDD
INDVVTYSNM NRRTIQATPP TKEKASAKRK TSNCSINNNN YINANNNYMT ILMKRDQFHE
DQV
//
