ID T1FRQ4_HELRO Unreviewed; 551 AA.
AC T1FRQ4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=P/Homo B domain-containing protein {ECO:0000259|PROSITE:PS51829};
GN Name=20211501 {ECO:0000313|EnsemblMetazoa:HelroP190143};
GN ORFNames=HELRODRAFT_190143 {ECO:0000313|EMBL:ESO10718.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP190143, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10718.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP190143}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01002732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01002733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095858; ESO10718.1; -; Genomic_DNA.
DR RefSeq; XP_009010987.1; XM_009012739.1.
DR AlphaFoldDB; T1FRQ4; -.
DR STRING; 6412.T1FRQ4; -.
DR EnsemblMetazoa; HelroT190143; HelroP190143; HelroG190143.
DR GeneID; 20211501; -.
DR KEGG; hro:HELRODRAFT_190143; -.
DR CTD; 20211501; -.
DR eggNOG; KOG3525; Eukaryota.
DR HOGENOM; CLU_494577_0_0_1; -.
DR InParanoid; T1FRQ4; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0016486; P:peptide hormone processing; IBA:GO_Central.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF3; FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..551
FT /note="P/Homo B domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010980893"
FT TRANSMEM 434..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..302
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
SQ SEQUENCE 551 AA; 62194 MW; C8FF8DD7B42CDB4B CRC64;
MLIKLCSLVQ AFLLVITTCQ SHYLNQWAVN IEGGEGVARE VAKDHGFVYL GEIMPDYYKF
QHPRIMKRSL EANDYHHSSL MSNEKVLWAE QQIVKKRKKR DISNMRAFND PYWPNMWYLY
IVFLTARSAN LIADDWVVNG VGRKVSHHYG YGLMDGTAMV EVARNWTPLS EHHRCATQSS
SQLVNLTIPS GQSESSVIIS NGCQGTDDAV QYLEHVECIV TLRANKRGEV QLFLVSPSGT
KSQLLPKREA DSSHEGFRNW SFMTTHNWAE NPNGSWTLIV TNKETSSNLR EWSLVLYGVD
REPEIYKRYL PSSTAAKLEV VVNAKADDNK NSNDAGSRFQ DGVKQFVGQN SGANNLTNIK
SIETKATSTN KTCAKDLYLL KDACLSQCPQ GYFPSENDHK CLPCSWECKI CRNADGCTVS
MEASDQTKWK SATFVVIVLL AIILSASLIL LFVFITRRRK NLSSLQDSLF SGENDKNNHN
RLIFHGDPLK NSEIHVSSLE CSDRNSARAP LLNNEESCSD DEIDLLTAND INRNYQRFDS
NNIQSNTFSL P
//
