ID T1FS66_HELRO Unreviewed; 587 AA.
AC T1FS66;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO08918.1, ECO:0000313|EnsemblMetazoa:HelroP190660};
GN Name=20211663 {ECO:0000313|EnsemblMetazoa:HelroP190660};
GN ORFNames=HELRODRAFT_190660 {ECO:0000313|EMBL:ESO08918.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP190660, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08918.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP190660}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; AMQM01003111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096023; ESO08918.1; -; Genomic_DNA.
DR RefSeq; XP_009012940.1; XM_009014692.1.
DR AlphaFoldDB; T1FS66; -.
DR EnsemblMetazoa; HelroT190660; HelroP190660; HelroG190660.
DR GeneID; 20211663; -.
DR KEGG; hro:HELRODRAFT_190660; -.
DR CTD; 20211663; -.
DR eggNOG; KOG4294; Eukaryota.
DR HOGENOM; CLU_020415_2_0_1; -.
DR InParanoid; T1FS66; -.
DR OrthoDB; 3414706at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 587 AA; 67229 MW; 8727B23ACBF7F66B CRC64;
MIQTIKLELL KYAENTSIKG ISKFVKSNNV FIKGLWSLFF IVSLIYMTFL MCKVFQNYYS
YPVNTMRGEL MDGALKFPDI TLCNLDIFAE GESPYMTKKK HSEILQSLKP KIERKIKKSF
QNHLVGEKEI GYEYFESLSQ HEVDERQNAD SYLDKIIENS FKILNSIPGY IMSLKKDRDK
SVDCPNFIVD CQFFDMDWFP IDAKCSVKNF TREWNSQYYT CYSLQMNEMK IPNGSTVRGL
SLLLNVGPPY PGELEYDFSM TRSQARGVQV NVHSPGTPPN FRWGFSLPPG TESIVEIIQT
ERIREDYPYT NSGCSKAEKM SQAPEYNYSR DLCMDFCKQQ HIKENCGCYT HLLNVPSNDT
KLCGYNVSDT GDNMLANFFC LIKFLNLDQS QKCRNTCLVP CKESVYDTLL ATATWPQASV
RRSIFKKYIE GNCTGYKDVV SRYASYYENY NASSSVSAPK LTEIEESFLE IKLGMKQGFP
FSEKDSQAYT TDAMVGTVGG MLSLWLGITV ASAVEVVELI CLLLNRLWDV KKPTCLRGKY
SVENMKNASE THPNEYGNFS NDAIRCIDCK AVIKRSDENG RNEFNKY
//
