ID T1FSY6_HELRO Unreviewed; 663 AA.
AC T1FSY6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Integrin alpha first immunoglubulin-like domain-containing protein {ECO:0000259|Pfam:PF08441};
GN Name=20211933 {ECO:0000313|EnsemblMetazoa:HelroP191408};
GN ORFNames=HELRODRAFT_191408 {ECO:0000313|EMBL:ESO05207.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP191408, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05207.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP191408}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AMQM01003891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096365; ESO05207.1; -; Genomic_DNA.
DR RefSeq; XP_009016522.1; XM_009018274.1.
DR AlphaFoldDB; T1FSY6; -.
DR STRING; 6412.T1FSY6; -.
DR EnsemblMetazoa; HelroT191408; HelroP191408; HelroG191408.
DR GeneID; 20211933; -.
DR KEGG; hro:HELRODRAFT_191408; -.
DR CTD; 20211933; -.
DR eggNOG; KOG3637; Eukaryota.
DR HOGENOM; CLU_414056_0_0_1; -.
DR InParanoid; T1FSY6; -.
DR OMA; TERVCAM; -.
DR OrthoDB; 2911572at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR028994; Integrin_alpha_N.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REPEAT 36..106
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 275..337
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 338..392
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 399..463
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 449..642
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT REGION 643..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 73440 MW; DD56FD0F99A1217E CRC64;
MILTTNEKIP MRHLRDFKIS LLIFFLEYFW DTECFNLDVS SATLKRGPPG SYFGYSITPH
KVGHHNSDII FLVGAPRDNA SDPLFSNISR PGVLYNCSFH DENTDCTPLP SFREFVLKDE
DYNDQWFGGV VVSQNIPSGQ ALACGHKYGK VSSARSETPG WCISLTNNLK PFKFHSPCNL
KHGGYFDYAV CQAGVSAFID KDGEILLGAP GAHLWRGVVF GGNLRNELDG EEGMSISTSH
NMAKQGRKVY VVGAPRSDNV GEVLLLQKVH AHTFLVKVRL KGQQMGSRFG HKVLVIDVNG
DGYKLDDLVV GAPLYHGVDS CGGAIYVYMS TKATSTASTD QTKNFHDPWF GSDIVSLGDL
DRDDFNDFAV GSPYEGRGRV YIFRGGITGP QHQPSQIIEP SSFQHLFNLS FSSFGFSLAS
NGFDLDSNLH PDLLIGSYLS DAVVLLRSSP VIDIRVSIKN EPKLINPNVN VCGNDKMRGR
NDGVGCFVMR LCFNYYFRKM RKSGKLVLMS HLKSNNSAKH NSSINDSVSQ AYFKFYVEKA
NTTPEKLPTA ETFSTSSQAP QMKLFNKTTT ASSQIIVHTT AKENKDNGNL NCVSHDVYLE
QDNHDYQNGI NFHLSYELIS FTPLNSSSSS HSHLNPVLSV ESSRGLTHVR RSQGELRDPT
PSL
//
