ID T1FT05_HELRO Unreviewed; 844 AA.
AC T1FT05;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=separase {ECO:0000256|ARBA:ARBA00012489};
DE EC=3.4.22.49 {ECO:0000256|ARBA:ARBA00012489};
GN Name=20211952 {ECO:0000313|EnsemblMetazoa:HelroP191468};
GN ORFNames=HELRODRAFT_191468 {ECO:0000313|EMBL:ESO05402.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP191468, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05402.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP191468}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=All bonds known to be hydrolyzed by this endopeptidase have
CC arginine in P1 and an acidic residue in P4. P6 is often occupied by
CC an acidic residue or by a hydroxy-amino-acid residue, the
CC phosphorylation of which enhances cleavage.; EC=3.4.22.49;
CC Evidence={ECO:0000256|ARBA:ARBA00000451};
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DR EMBL; AMQM01003934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096365; ESO05402.1; -; Genomic_DNA.
DR RefSeq; XP_009016717.1; XM_009018469.1.
DR AlphaFoldDB; T1FT05; -.
DR STRING; 6412.T1FT05; -.
DR EnsemblMetazoa; HelroT191468; HelroP191468; HelroG191468.
DR GeneID; 20211952; -.
DR KEGG; hro:HELRODRAFT_191468; -.
DR CTD; 20211952; -.
DR eggNOG; KOG1849; Eukaryota.
DR HOGENOM; CLU_337491_0_0_1; -.
DR InParanoid; T1FT05; -.
DR OMA; HYRNICH; -.
DR OrthoDB; 5479815at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0098813; P:nuclear chromosome segregation; IEA:UniProt.
DR GO; GO:0000280; P:nuclear division; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005314; Peptidase_C50.
DR InterPro; IPR030397; SEPARIN_core_dom.
DR PANTHER; PTHR12792; EXTRA SPINDLE POLES 1-RELATED; 1.
DR PANTHER; PTHR12792:SF0; SEPARIN; 1.
DR Pfam; PF03568; Peptidase_C50; 1.
DR PROSITE; PS51700; SEPARIN; 1.
PE 4: Predicted;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 645..741
FT /note="Peptidase C50"
FT /evidence="ECO:0000259|PROSITE:PS51700"
FT REGION 164..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 96231 MW; AB9E9CF7C9A761AD CRC64;
MNVVRWVRLS KNKTISLKEM AHSSSTFDVK NLLGILFSKL SVLSLHSALK INDHEVLNTL
LNENTRYFDD VNCLGTVHVA SDATKTMNKK KNIKTYNKLK DVKRRSLSDY HQIIPDLIEA
TIIKFSSKFS WPSQCCSYLS DMQLLKSSMA TLLDGESFVD HSDHNSFHSS SSTTTAPKKM
SESPVKKVSA DDDVFLPPEA PVKKARKPKP LKLEISRSLS SHTFLSDQQD GSMKKGKKLK
SIDDKELSDI LAETLSLEDR ECSEEAGTKT SESCLSADLL KCFYLMHHDP PIVHYRNICH
LLALSCMNDG LSNDVQVAYY LAESVAVSFR HMTLVNISKK IRNLSEELDK TSPPPSEALL
QENVETLQHL EVCKDYIQFN KECHYIEQFI EHIPSDWSVC QITLVNIEKQ RRDQLILTRF
VHGETPLNIP LPHVDVDERR TLLEQFDWLL KENMNTMKVT NKKEWWDRRQ SLDEKLDELL
ESFEKEWFSC WIGGLMGRLV DAKNEEAIDN EVHNFMKSFP FCNKKQTRFI KCLFNGAHLL
DNRLILQALH FLARTSGKSQ SVEPSSLKQY LPLVQSIANK LNLKEALRGP VVFILDKQIQ
HLPLENMPSL MNERITRQLS LHCMFGQLVC QMKQEKSILR RGVNRSSVFY VVNPDNNLPS
TQKVFQDWFE TKEPEWTGVI GKPPTSDQLS TNLSTKDLFI YSGHGTGSKY LSGGSLQLLN
CRSAVLLMGC SSGRLWTYGQ LEPVGMINHY LLAGSCCVVA NLWEVTDRDI DRYMESLLKN
WMACGKEEED GSDDEPKTSP SLRPKTCLLE NAIKSRLACH FRFLIGAAPV VYGFPIRVDF
NKNI
//
