ID T1FTR6_HELRO Unreviewed; 3257 AA.
AC T1FTR6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Tower domain-containing protein {ECO:0000259|SMART:SM01341};
GN Name=20212213 {ECO:0000313|EnsemblMetazoa:HelroP192253};
GN ORFNames=HELRODRAFT_192253 {ECO:0000313|EMBL:ESO01756.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP192253, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01756.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP192253}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01005017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096743; ESO01756.1; -; Genomic_DNA.
DR RefSeq; XP_009020410.1; XM_009022162.1.
DR STRING; 6412.T1FTR6; -.
DR EnsemblMetazoa; HelroT192253; HelroP192253; HelroG192253.
DR GeneID; 20212213; -.
DR KEGG; hro:HELRODRAFT_192253; -.
DR CTD; 20212213; -.
DR eggNOG; KOG4751; Eukaryota.
DR HOGENOM; CLU_225316_0_0_1; -.
DR InParanoid; T1FTR6; -.
DR OrthoDB; 5484321at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 2.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 3.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 3.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2584..2626
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 101..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1687..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1910..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1959..1987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1999..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2246..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3102..3129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3167..3190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1999..2027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3102..3116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3243..3257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3257 AA; 361913 MW; 8DAC0EB37666B85E CRC64;
MSTPAQEPQK RKRLNSFAQQ QLRHHSFLGH SYLFANDELR EHNEDRIRFS SEPQNNLQHK
EMNDESDQDF INFFDNLLSP TQLDFLGERN ENWEHDLLLQ QHNQNVKPNK RRHSTKSKEY
ENEASPKISE LKDVSEIENI TTSTEISSFS FDHNILDYPP PIRNVSNERC VPSVLALCAN
NTNTSWTSSM ATVNFEQQPQ NDTSLLSSTV LSMTNNLTST SATDLHFDES ADVMVEPINK
NDQIVCKSSS EINNYKELLR KDNTPTKHLQ NDDALSLFFS TPKPKSFKKL KKAPKRKSTN
VKKRSFEEDL NEELMEFGET NQTKHNFLIF TDSINDTVNN RVLDDSKMYV SIENNDEIIS
EKCSKHINSG GINFSPNLMS PRKPIKKFTS NMNVGIDSII GNRHDHTSSI HDSDINKVNN
SHDDERGNSM NDSMKDLSLL QIGRRLEDTI SNSNNSHPIP ASSNSMTTTD HLCNNINNQP
ISSVMIPGND MKHTLYKTPS YNNHKSMKES SFEVPSTIKQ SKKHLLYHST ESCSHTSPSS
SSTSHPTRQV RLQTSTPIRS TNVNHHRTKL FFSTDNSSAP LPTSSSSSTF TSTSSASSSS
PKSTSAVSAS SFSSSSQSLL FNTTVIKKLT ENSLRSNRDE GEDKRDATCA NTSSTIQNDS
NNSNINISSK YKTINCISDS INASKEVTNN DLSSNSNDHA SNSKNLLTSI QCARQKKFIY
PSRSQIVQSH PSNVFNLNSN YRTRDTNYCN DSSVSSLFNI PLEPVSKWKK EDLRKITLYA
NLRRINMDDD VKLRAGNISS LVNVASCDKQ DMHDDINDTN NNGVKINNII DFKGVFKAAS
NADSINFNDT SAVNDDNISK NNTNGSINSD NDDDVKRDVN IRGSSYHNFR ENYTTTCTHF
QTDKMDISVG EDKASSKNFS VDSVKTNNNS SDYSSSKCGN NVIDCNKYEI NFSVNNIKNI
AQITNNNATN NINDKNSMKN VNNNSTYNNK NNNVSHTNSN TNTYNNGNTN NNNNSTGTGF
TTARGKCLSL SDCKLTKAYK LFADIFDDDG VAVDDNNNIN SSTNNNINSS TNNNINETVA
DDINKSTTIG FSQHGTLQSN DEMLKNGIDN SNPKDLLQIC ENFTGNICTD HNMQLNNNYK
YNNNSNNNNN NNINNNVNLK RKHLSDEEND VDVVVTKKSF KPSYSDNDNI KNNNNNNNNN
NNIHNNIYNY SNDNNNISNI NTNPSLSYEH TMTALSNQND NRNYANNYVN NYNYVNNYNY
VNNYNYNDDG IKNNDVSMIL DYIANSVFDE SVNTQYLGNT HSNNFNNNFV PTVTATDDSL
HQHDEDRNIS ATEAFEDVAI LNLVADDDNA NCHSCDDENC NNGDVDSISE NVGCGESKVF
GISTRPVLPS PMPILVQVEP FGSSAHHCKE DASVAVAVEC NTSILSDGPP ILSPVTPFAC
GNKAADKLEW NEECGDELVV GEGNAKILEK SDCEKTLLKN DDSYQSSNIE RNNTLRNNEC
DATNCRNPNY STLKNSFQDT NINPIYSKES QNKNHFNNGN SLMFTGFQKA SGEKVHIERK
FLLKAESMMK NCLVDDDANL DVKLIASGEH GDVVTAPSFP ALTSSSTSDA TMKTIMNSSS
SLSSLSVTPS LSSSSSFATS SSSSLLLSSC FQTASGKKVG VSDGAVVGMR GLLGDVLVEN
DDDDVINNNI NNHNDDNRNK DNFNRTKKGD NIRCNNFNKP RKWDQKSSLT IPSSSSLITS
SMTSSIATSS SSLASSSSST AAAALSSSSL FQTASGRCIE VSEASLAHVK SFLRDDDEED
DNVANDDDNN YVTRDFNKSQ NMTSCSKIIG KNVSSQAKSK PSFITSSALS AASPSLTATA
SSSSSFVAMT SSSLVATTSS SSLSSLFQSA SGRKIEVSEA SLSYVKSFFR DGDDENEDDD
DDNVGCGDGT LMNDNVDKNK DFGEKDTKMC NNIYNNINNH GDKSNNSDAN NSKNNTNNGD
GSDSSKSCKK YIIISDNRTA KKSNLHPRQF SSNISGKNLI DNDNTGTSRV RSTEHSKKFV
TPYRSATTSQ QPQSLQAKNP AAITKLLENN EPSAGNNTSS TVCQPATQQP TATKLAYRTA
AITTSQRQHL QQARAQQQNI MQSKIQNNDV RHQFGSLYQS KNNKNITRLS LRDFVAEYSN
NNCQQQHIHN SEDDNSTIYK LALGVNAMNA EDFKFHVSIF CNGDDDDDVN DVKSGVYDDE
NDEGVNEMSA NNNETNISLI SSALKQTPDA DEDNGSTYID KKNSSNNTAT NSCTNSSTNR
WGVLKLEDGG TLVADDDGYI SKVEMYQALL TTNGVTPSMV TIEWTANHYR WVVWKLACMY
RMHPAVFCGK RMMSPQYVMK QLKFRYDTEI LACRRSAIKL ICERDDSSKK GMVLCVAHIT
RKSNNNDGGE EDEDDGISDS MLVNESCLQS YGNTNSGFDR ADVRDIKTNN SYISASYINN
KTDIKSSRYE LLLTDGWYCM DALVDDHMDT LISKRKVQIG TKLFMVCSEL AGPSEACSPL
EQPNGLALKI FSNCTRRARA GCKLGFVTLA SSIPRWPLSS MSGCGGNISC LDVVVVRRYP
TMYHEKFVEG VKGVMRSERL ERKYDRMFQR QRDKKMEELY NKWQREFLEK TCCGEKKSGN
INFVDSQYNM DGDDGGEMMV KRKEEMNAFM EMKMRGVADE AGMKRLVTPM FKCIIRGCHW
RDIDAASEAQ LSVWNVSHEV SELLQEGTRV LLYNVIPNNN NNNSTTFRNI YKDSNDWPLH
LTTSRLTQYH KMKIDSNLLN LIYTPRSVTR FIDILHELSH SDYDVVGLVV RVTMQNEVKL
ENKNVQIVYM VDEWGGYGAV EFWGGLCAYG LDGVIHQGIV IGCCNLKSRK NSLKSSTAFN
KTFSTSFDKD KSLVSNSSFN ASNISHNNSY NSTIRKNISD VASNNVATNS AIASLQATDA
TDISTNPSHR HLINGINSMK VLVKSDKQFL QRHLQHINNV LLMSVSTSTT LPSLSLISRS
NSEKENKGNA NDIKHAIFKS YNNKSVAEAR NSNQIIGKKF QNINNSLLKV CHNNSFNSPT
SASSFIYDDV ISAFEHDDDE LYRSICTQLI NNSINNFKEI NSGATNNDNS TDDNNNNNTY
DDKHNDSKSD IKNCTLEINR FNEIIISTKD NSITDKKDDG IVCAQSKVND SRSTEDSTPV
VSTYNSTQMG NTSMERITTL SSLPSGLRSG KRKAVSSSKS SKRLKIKRKH DDDKDGENDD
DAQNATSLEP TCLSSTQ
//
