ID T1FTU6_HELRO Unreviewed; 522 AA.
AC T1FTU6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
GN Name=20212243 {ECO:0000313|EnsemblMetazoa:HelroP192345};
GN ORFNames=HELRODRAFT_192345 {ECO:0000313|EMBL:ESO01460.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP192345, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01460.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP192345}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
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DR EMBL; AMQM01005121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096785; ESO01460.1; -; Genomic_DNA.
DR RefSeq; XP_009020696.1; XM_009022448.1.
DR AlphaFoldDB; T1FTU6; -.
DR STRING; 6412.T1FTU6; -.
DR EnsemblMetazoa; HelroT192345; HelroP192345; HelroG192345.
DR GeneID; 20212243; -.
DR KEGG; hro:HELRODRAFT_192345; -.
DR CTD; 20212243; -.
DR eggNOG; KOG2315; Eukaryota.
DR HOGENOM; CLU_013809_1_0_1; -.
DR InParanoid; T1FTU6; -.
DR OMA; WNPNSKE; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 217..406
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 478..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 59104 MW; 54C933BE60EEFBD0 CRC64;
MAELESVSNL YSTIISRSAK TTKIEWMNSS KVLELPACRT LTFNKNGDFL AISDSQGVRI
VSTEDYEKPL WQVAKPKTVE VKFSPLAKYL AIWEPVSKDK TTETVPCNLH VYNWRENKLV
MEVVHRKQSD WSPQWTSNEF LCSRLANNSD ILFYEDHNFS QVKCKLHMPK IMCYSLAASP
ASYHVVISVL GSKGEPSFVR LYKYPNFSSP SDALANKSFF KAERTELYWN NEGTSLLTLT
FSDNSEESYY GEQHLHYIST KQESCQVHRA KPGPIYSIAW HPNSKEFCVV YGLMPAKATL
YNLKCEPVFD FGTAPRNLAY FNPFGNLLCL AGFGNLNGGM EFWDVEKHKM LNKFSVVDTT
YFEWCPDGVH FLAATLSPRL RVSNGLKIWH YSGIKLRSWE TNELYSAIWK PVKEGTHTEP
TLKFTASQAA VVSATATAKP AAYVPPALRN KMTSSTSGTP AATSAAVYKP KFREDYELPS
NLKEQENKPM SKSAMKNKKK RDNKKAKKLG SSPEKADDDE EE
//
