ID T1FUD5_HELRO Unreviewed; 843 AA.
AC T1FUD5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Formin-like protein {ECO:0008006|Google:ProtNLM};
GN Name=20212431 {ECO:0000313|EnsemblMetazoa:HelroP192864};
GN ORFNames=HELRODRAFT_192864 {ECO:0000313|EMBL:ESN99595.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP192864, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN99595.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP192864}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR EMBL; AMQM01005831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097106; ESN99595.1; -; Genomic_DNA.
DR RefSeq; XP_009022354.1; XM_009024106.1.
DR AlphaFoldDB; T1FUD5; -.
DR STRING; 6412.T1FUD5; -.
DR EnsemblMetazoa; HelroT192864; HelroP192864; HelroG192864.
DR GeneID; 20212431; -.
DR KEGG; hro:HELRODRAFT_192864; -.
DR CTD; 20212431; -.
DR eggNOG; KOG1923; Eukaryota.
DR HOGENOM; CLU_003597_0_0_1; -.
DR InParanoid; T1FUD5; -.
DR OMA; CHGLDEY; -.
DR OrthoDB; 471257at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 2.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF4; FORMIN-LIKE PROTEIN; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 2.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 1..373
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 397..798
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 784..816
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 73..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..362
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 94846 MW; 177CBD92AE36FCEC CRC64;
MAGPKLPKLK KTSSDMTSTQ VLRDLEISLR TNNIHWVRDF LSDQLNGLDI LVAYLSLALS
VLRLEVMNSS ASSEHDGSLI NTSTTSSTVN PSRSSFLGKS ASTLSKKMKQ SHSKLGLADA
IDDIHVGVQC LRAIMNHQHG FNLVFQHTQA INCITLSLNH KNLRTKTLVL ELLAAVCLVS
GGHEIIFKAF DNFKEVCGER RRFETLMRNF LHFEEFHIDF MVACMQFINI AVHSVEEMNY
RVHLQHEFTL LGLDQYLNTL SNSESDRLLT QVNAYMDNKI EVRLLLEDSD TKNMALDHAA
ELDSELSFVD KESELATLKE QIKRNSFASS LPPTLPTSSS SPLSPLTPPC PPTSLNIPPP
PPAPPMMPLG VPGGGMMLPP PPPPIMGFGK VNATVPIKKV LHPRHRLPIL NWVAMKPNQV
KGTVFADLDD EKLYQTIDFH KFEDVFRLNQ FALDATDEVD GTPKSERRFS RRPEAPSLLE
PNRLRNVAIT KRKIEMSNEM VVSAIQNLNL KMLSLERVEA LLRILPTEQE VKAFREYEGE
RKSVEVLADE DKFLIALTRV ERLQQRLKIM SYIGNFFDSY QHLQPIVDTR STSDEHRQSL
THFLATTITS KFPDLLNFDL EFQCVEKASA VSLDNILADV NELDKGMQMV NKEMDGWKDR
SSPVVATLTE FTSRSADLLK KLHDDCTTAQ ESYQAVVSYF GETSRTMVPT AFFSLFVRFT
KAYRQSLVDL ENWKKQETLQ SVSSKEKLKG KNQQLGGAAG GASVASEMKR KFKQVKEKRV
ISREEVYHGA LEDILLDLKN EPYRRADGIR RNNRAKPPPA PPQPQPHAAA ANVNKTVVDG
VKT
//
