ID T1FUK2_HELRO Unreviewed; 1876 AA.
AC T1FUK2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=B box-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20212498 {ECO:0000313|EnsemblMetazoa:HelroP193046};
GN ORFNames=HELRODRAFT_193046 {ECO:0000313|EMBL:ESN98318.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP193046, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98318.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP193046}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AMQM01005963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097182; ESN98318.1; -; Genomic_DNA.
DR RefSeq; XP_009023653.1; XM_009025405.1.
DR STRING; 6412.T1FUK2; -.
DR EnsemblMetazoa; HelroT193046; HelroP193046; HelroG193046.
DR GeneID; 20212498; -.
DR KEGG; hro:HELRODRAFT_193046; -.
DR CTD; 20212498; -.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_236315_0_0_1; -.
DR InParanoid; T1FUK2; -.
DR OrthoDB; 5347036at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd19756; Bbox2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR PANTHER; PTHR25462:SF229; NHL (RING FINGER B-BOX COILED COIL) DOMAIN CONTAINING; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 245..292
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 567..608
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1010..1037
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 421..452
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1876 AA; 209796 MW; 36B1738CFEAD737D CRC64;
MASGYRTSYL QALSSPSSSS SSSSSSSSSA LNSNYLKHWS SLKPVPHSPS SATSTYNNNN
VTNPMKSYRY NSHMQHNNYD DYYSSNSSNH SYYSNLNVPA TKTPSSSPSS SYLNIPKSFS
RLYPAVSTTS YQSTYHKTTL SSSSSLLVSL SSSSSSSANT SSASSSATII AATKYLSTTT
QNLLARKNYK FLDNNNSNNN NNSNHNHNNN TRFSGNNKGE NNGNINCNNV DVELIKEIYN
QLLTCRVCFK SYVKPKTLDC LHTFCEKCLL KQYKQQQDEL KSQVQDEQPP CNISSLAIKE
LVDSFNNDEM KNNLLAINHN DGSNIITISK NVSSSNNYNR DILKCPLCST ATNIPEGKVK
VLPNSSLVHS LNRLIRRVCQ NDSRIFRDHH QFRHRHLRRL RHRQQQHQRG EKFRMKNDDG
DVDDEDYDDE EEDNEDGDED DDDDDEEEEY ASEDAGLELI CEICHKDDEG ADDGDPVESC
DVFKNDVNPN NKINNDLMRA AANEQQQQNQ TSPNAARTKT KHRLPKLATV ECLDCSCKLL
CNDCAKVHME TKITQSHSLV RVEILRKGDL CCAEHQRENV RFYCETCDSC VCIMCTFYEH
KTHKIITFSD AIKTNLPLLM SKVAKCRSVF EQMKNHLNAI NNFEECFLKT EIAIRERAEE
IVKFANDCEK QSLIELKRFL NDESVIEFLK KRRHFEMAVS STDQLFQLTE RLLDGKNVEL
FLAKRKLEEQ MNDLLNWSFT EIPNLVAKPP KFKKSAKNIV FGHFILLHNK NESKSTESLS
SSENEDVVSF DDNINNSSVA NISNKNYGNI SCYRESLIFT NKTDKYLSGG DIGKNHNTIN
MNNPNNSNIN SFINDNFIDH TNNSSSDDDD EGSDISSCSV KILESSFDNE DNEDDVDNED
SDIHSDIISN SRAEQQKFEN KHLDKKVVDS INSSNEEEIV DEDNVDTTPL ESLKSISELE
TCNQSHSHLP SSPSSSSSSS SSDENEKSQL WEIDGNLKLQ QSLNQNSTVI SKVENSKECL
EKLIENQNVE IEKMEAGTMT EKVFFENKST LTLPSSVQYV NKGTSTATTI VADKSTTTTT
TNVSSAYRDF LESKTPKQMS ISRGTMTNFM PDNKAQIFKE KLNLLEKTEF NCHSKNNKEF
KLDTTDRASS PIKFIKCDKT TMFNGLVEKK APVDVFCRAG IIGKPKKIIS DSISSLSSIN
ENIDEESEEH NQCSERQTEN VESLSNVVFD VSGNYVSDDG FNNFKKKSNF TKLHSFELGQ
SEQLNKKSLL RAQKSVTHYI NNRSSAIVHP FLSNNLQRQQ QLMSVQGNVN TNINTINSND
CKLTTNMNDN VDNSLDILQQ PNQQQKQSSH QNEQLQLAVQ HQQQFREQRQ KLDNASKLYV
EIGTNTTAPT HHDASTGTDS PPVVEKMAEC ISKLKTVRHR LECFQSSNSV SVNSNSNNSV
SSSGNNSDDN PTQNSNNLCS INKNLKIVEE IIKTSDIANS GSNVLGKSSR SNSINNSNAA
DVIVNKIECR RNGNEDDDGA VSSGTNCEAT DANFKDLKTT SAPPASVLSS LTSSSFATTN
SSTTTSVETI HSLTNGKKTN ENNLSNNNAN NGNNYNSNTN NQIFNAAKQL VSSGNESVLA
RRQRYSANIS LNTNKPINYN NKATKRTNYN SQAVNSNSES SSNNNSPNLE RSNKLGTVNN
NGLSQQNVAK RTLKCRKASN ITTNPSTTNF SAANNFSLCN AGEISTSFNP TANNTTLTKG
NDCKNLETNN PNFFELSDSL QSESGEEIDP VLLKSILKSA APSVTQQQQP DLAQEPQQFV
SKSPFARDID RSFSANLKKR LQNSPISRRY HLQQQHQQQQ LQDQQTQNQS QSDTISILKA
IKARNKSPRP TKKTLK
//
