ID T1FUN0_HELRO Unreviewed; 428 AA.
AC T1FUN0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN Name=20212526 {ECO:0000313|EnsemblMetazoa:HelroP193117};
GN ORFNames=HELRODRAFT_193117 {ECO:0000313|EMBL:ESN98176.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP193117, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98176.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP193117}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01006060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097222; ESN98176.1; -; Genomic_DNA.
DR RefSeq; XP_009023860.1; XM_009025612.1.
DR AlphaFoldDB; T1FUN0; -.
DR EnsemblMetazoa; HelroT193117; HelroP193117; HelroG193117.
DR GeneID; 20212526; -.
DR KEGG; hro:HELRODRAFT_193117; -.
DR CTD; 20212526; -.
DR HOGENOM; CLU_732115_0_0_1; -.
DR InParanoid; T1FUN0; -.
DR OrthoDB; 2967350at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR45713:SF6; F5_8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00024; PAN_1; 1.
DR SMART; SM00473; PAN_AP; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR PROSITE; PS50948; PAN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..428
FT /note="Apple domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010981030"
FT DOMAIN 167..251
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 428 AA; 48696 MW; D196632571304AE9 CRC64;
MLFFVLTFIN LVVSVGFARN VLLRKPSTQS SCYDTTCNKY NASLAVDGDS NPNFDYTHCF
HNTFEILEDR WILVDMLIAY KIDYVVFWSR DSDSERNEKF IIGLTNVNYF DPTSDRPLRG
KFPICGQYPD PPQVSSPHRV NCGNNVTASR YVIAQQYSLA LVGFVVCELE AFPREEKIWR
HREGMKLSGL TIRTTKARTV YHCVILCLQS TGCSSVNFNR DSKTCDLNTG TVENVTNFVG
NQSCDYWQRI KLDSKLIEQN YSVISQKNVL LLKPATQSSI YLENNAPHPG SLAVDGDKNP
DIDLGGCFHA GVEPLKEFWV LVDMIIPYRI DYVILWSRKY SVYTPRNDNF IIGLTNVNYF
NLLTNQTIRG KFPLCGVYPY PTQPSFGHRV NCSSNLPASR YVIAQQAENA EYGFCICELE
AYPMKGKL
//
