ID T1FVD3_HELRO Unreviewed; 963 AA.
AC T1FVD3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=PIN domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20212779 {ECO:0000313|EnsemblMetazoa:HelroP193801};
GN ORFNames=HELRODRAFT_193801 {ECO:0000313|EMBL:ESN94819.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP193801, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN94819.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP193801}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01007117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097563; ESN94819.1; -; Genomic_DNA.
DR RefSeq; XP_009027169.1; XM_009028921.1.
DR AlphaFoldDB; T1FVD3; -.
DR STRING; 6412.T1FVD3; -.
DR EnsemblMetazoa; HelroT193801; HelroP193801; HelroG193801.
DR GeneID; 20212779; -.
DR KEGG; hro:HELRODRAFT_193801; -.
DR CTD; 20212779; -.
DR eggNOG; KOG2162; Eukaryota.
DR HOGENOM; CLU_011872_0_0_1; -.
DR InParanoid; T1FVD3; -.
DR OMA; GICLDNP; -.
DR OrthoDB; 1356823at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR CDD; cd09884; PIN_Smg5-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR Pfam; PF13638; PIN_4; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 28..110
FT /note="Telomerase activating protein Est1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10374"
FT DOMAIN 117..255
FT /note="DNA/RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF10373"
FT DOMAIN 705..790
FT /note="PIN"
FT /evidence="ECO:0000259|Pfam:PF13638"
FT REGION 185..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..291
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 109879 MW; 5D656C01EA0CF086 CRC64;
MRMISKLKRL QEYCEKLMFT WPIEYGKKVE EVLWRKGFYE VIQLVRANVK ELSTDVNIEK
AFHSHLLSAI GYYNHLLLKI CQTFNLQLDN INLFSWPSNK TRYQHDMDKN RCSKRSAQHY
YHMAITIMPS SGLPYNQLGT LAGNDVDESL TAAYYYLRCV VSPLSFDGSH SNLIRLFQLN
NNNKINNNNN NNNNNNTSNN KNNKNNHGYR LPWKSDDDDN NGCNTKNDDD GGGGILEEVK
PKEDREIPGD KNRPLVKDYK SVKDYGRKKK ASKMCRNKYT SVRKRKKGRH SSSSSSSNNY
DVIINLYNNN NNNFQNNNSV SRQQLQQQQQ QLNYPFLVNS YNTAATGIND ISNSWLEDIT
ILLGRKMMMT TTKCDNDNDD DDDVYSNNKN GAGGGGDDDD VLLSKHVPIP PGFEESLELR
HIQEISQKLA TFDIDTDTDV NQTDIAESDE EKIKEDDSQS KLKKNRNEFL LASLSRNGLL
LSVKVLCDWL AVNPVIVATC AKISSSIWFR LATLLNLLPS ETDITSSATY VSSNAFFKRI
VDTELSQLAK THQEISEKPT SYLYLPLIEN KHLREFPPLK KAYSFIDMKS TIFLNSIQQV
VLRICRMRHF GRQMSTLKEL KFTFNSETGM YHSRNFQDGD DDEDEKVFNM NINSSQNDPN
LIEKKMLDME AKRNQLMRDM AQLRLQSEVD KLQGSLVQSY PPYLVADVTS LCDGWHLIKQ
MSLSGRFIVI IPLAVIDQLD VMKKDSVKAR NAIRWMEFEL KKGGRYLRVQ KQHETLLQST
STPRRGKDDK VTWRHIKVID CCEFILKNNA KSIGKDDDNG EANKSNNNSN NNGNDNNKIG
QEDDDDDNIE DLKVKLVAPS SSSQATSSSS PIVCLLSSSF SVHSKELNYS LKDALTRAIN
KDFTSNVSIT FTSAGKNLTA VIIRRLIIKI TVIIITIKIA SKRNTVRRLG NKLETILIFF
SVQ
//
