ID T1FVL2_HELRO Unreviewed; 433 AA.
AC T1FVL2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
GN Name=20212858 {ECO:0000313|EnsemblMetazoa:HelroP194029};
GN ORFNames=HELRODRAFT_194029 {ECO:0000313|EMBL:ESN93487.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP194029, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN93487.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP194029}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the battenin family.
CC {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
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DR EMBL; AMQM01007378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097605; ESN93487.1; -; Genomic_DNA.
DR RefSeq; XP_009028353.1; XM_009030105.1.
DR AlphaFoldDB; T1FVL2; -.
DR STRING; 6412.T1FVL2; -.
DR EnsemblMetazoa; HelroT194029; HelroP194029; HelroG194029.
DR GeneID; 20212858; -.
DR KEGG; hro:HELRODRAFT_194029; -.
DR CTD; 20212858; -.
DR eggNOG; KOG3880; Eukaryota.
DR HOGENOM; CLU_029663_0_1_1; -.
DR InParanoid; T1FVL2; -.
DR OMA; YIPNIWI; -.
DR OrthoDB; 2912995at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; BATTENIN; 1.
DR PANTHER; PTHR10981:SF0; BATTENIN; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 2.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU361113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361113}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 131..154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 166..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 275..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 338..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 365..391
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT REGION 210..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 47023 MW; 0B46B2E3678BC1DF CRC64;
MDNEDETTSL LRKKEKSRLT RNLIGFWLLG LTNNFGYVIM LSGAHDMLTP FNATTANASN
EVNRTGSLVE DCNPVGTGAV LLADIIPALL VKLMAPVVLQ KIPYVFRICA VLLFGVASFV
LASFGGSEHV YVLNVIATWS SGTGAAGLLG STSYAGLTSL GLTPKVTLLI MIVVPCLMAC
SYFLLLVSPK PGLLTSPSSV CCRRNHLRDD EDDDGRAARP DGEVGFAGCN NNDGHDGDDD
GGGGGGSADD DDGGNNNNNP GEKTAMQKIK SLKPILKYVA PLFFVYLIEY IINQALYELI
IFKNSWLAIP QQYRWYLVLY QVGVFISRSS VNFIHIPIVW VFPILQFAVL VLLSCQVFFH
YIAYIFIVFV IIVFEGLFSG GAYVNAFYAI LHTPQVPQED KELCMSVTCV SDSCGIALAG
VLAIPIHNYI CSL
//
