ID T1FWX2_HELRO Unreviewed; 469 AA.
AC T1FWX2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=ZZ-type domain-containing protein {ECO:0000259|PROSITE:PS50135};
GN Name=20213320 {ECO:0000313|EnsemblMetazoa:HelroP62222};
GN ORFNames=HELRODRAFT_62222 {ECO:0000313|EMBL:ESO11955.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP62222, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO11955.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP62222}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO11955.1; -; Genomic_DNA.
DR RefSeq; XP_009008675.1; XM_009010427.1.
DR AlphaFoldDB; T1FWX2; -.
DR STRING; 6412.T1FWX2; -.
DR EnsemblMetazoa; HelroT62222; HelroP62222; HelroG62222.
DR GeneID; 20213320; -.
DR KEGG; hro:HELRODRAFT_62222; -.
DR CTD; 20213320; -.
DR eggNOG; KOG4286; Eukaryota.
DR HOGENOM; CLU_001187_1_2_1; -.
DR InParanoid; T1FWX2; -.
DR OMA; VKITIRI; -.
DR OrthoDB; 5405762at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0099536; P:synaptic signaling; IBA:GO_Central.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 6.10.140.70; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF14; DYSTROPHIN-1; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 227..283
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
SQ SEQUENCE 469 AA; 54541 MW; 675810A471BCD2D6 CRC64;
HITSHKSEST HWDHPEMTNL LHDLSTLNAV RFSAYRTAMK LRMLQFRLKL SSTSLKTVHE
YLISSAPQSR DATVGVSDVV TWLLDLYPAD APTFDLTLNW LFNVYDIHRT GHFNLLSIKV
ALMLLSNASL EEKFKKLFEL VCDERALMSS TQLSSLLIEL MKVPQQLGED YSFGGLNVQP
SVKSCFERAM CDDMIDCDQF LEWTRMEPQS IVWLHVMHRL CAAERSLHQV RCVICKIMPI
SGIRYRCLKC FNFDMCQNCF FAGSTTKNHK LNHPMQEYSS EATSGDEMRD LKVVLKNKFR
SKQYFKKHPR LGYLPVQPSS SETNTIDRIL QEEYNQLKLV RSEPSLFCRE LSVDTGSEVL
NKEDFLRQHK NRLEARIQYL EGHNRQIEST LDQLKQIRFE VIAICLEKHF HITSVKITIR
IIQPENMRIV TYTKTPQVEA FVSSYQQNDL YHPPPPFRNS QNQINNSAF
//
