ID T1FX87_HELRO Unreviewed; 687 AA.
AC T1FX87;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN Name=20213435 {ECO:0000313|EnsemblMetazoa:HelroP62964};
GN ORFNames=HELRODRAFT_62964 {ECO:0000313|EMBL:ESO13121.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP62964, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO13121.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP62964}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO13121.1; -; Genomic_DNA.
DR RefSeq; XP_009009841.1; XM_009011593.1.
DR AlphaFoldDB; T1FX87; -.
DR STRING; 6412.T1FX87; -.
DR EnsemblMetazoa; HelroT62964; HelroP62964; HelroG62964.
DR GeneID; 20213435; -.
DR KEGG; hro:HELRODRAFT_62964; -.
DR CTD; 20213435; -.
DR eggNOG; KOG3727; Eukaryota.
DR HOGENOM; CLU_011611_0_0_1; -.
DR InParanoid; T1FX87; -.
DR OMA; DELWIRQ; -.
DR OrthoDB; 5399911at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0030055; C:cell-substrate junction; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17095; FERM_F0_kindlins; 1.
DR CDD; cd17096; FERM_F1_kindlins; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF13; FERMITIN 2-RELATED; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 354..469
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 139..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 78783 MW; 76A4EEC15691F813 CRC64;
MTSADQTWPL NIHVTDLQSD VTIRVRDDMH IGGVMIKLVE TMGTGQDWSD HSLYWPDKTM
WVSRAKSTLE RYGVRPHDKL VFTSMHKNIK IQLPDLTVPF VRVNFSVNVF NVNLNICKEL
GIRHPEELSL MKKIDPDQLK KNQGVSGKRK DGLPTGMNQK LAGSSDGLNE GTLSRTYNPY
MASNSSPNRS FNANGMFTPG TGSIDNLAFH TLNISSSSSN RIVNSTSLVL PNLLPKIRNY
SEAARMNVAW LDSSLSLMEQ NITENDTLLL RYKFYDFYDL NPKYDESRIR YIYEQAKWLV
LSEELTCSEE EIILLAALQV INIINTILSR NNIINSRSND NSNNFGISGS GSSGSSGSGG
IVCRATRIRD CMRCYRPRKF QLKTFAKYLF ILKNDKLFIY KQPNKNDYGD DDVGASESFS
LSSAFDVQED KYVIKLILPY HGATDELWIR QDNEEQFVKW LAALRILHRG KSLLDHVAYE
KEKKSVSSLI NIQKFPNKNN NNTNKNTNNN TTNNNKLQAD DLKPERILPP KFGAKSKNFK
NLLRKIIDIY SNISQKTYIE AMLDYIKVWQ MLPKYDFRYF IIKIKDSKKE ELLGIGKDRL
VKMDLKTGDL LKTWMLKTIQ SWSVNWDIKQ VHVSFDLEEE LIFQCLTTDC KVIHEFIGGY
IFLSMRSGDK NQALDDELFH KLTGGWN
//
