ID T1FXP1_HELRO Unreviewed; 944 AA.
AC T1FXP1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20213589 {ECO:0000313|EnsemblMetazoa:HelroP64096};
GN ORFNames=HELRODRAFT_64096 {ECO:0000313|EMBL:ESO06352.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP64096, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO06352.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP64096}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096324; ESO06352.1; -; Genomic_DNA.
DR RefSeq; XP_009015720.1; XM_009017472.1.
DR AlphaFoldDB; T1FXP1; -.
DR STRING; 6412.T1FXP1; -.
DR EnsemblMetazoa; HelroT64096; HelroP64096; HelroG64096.
DR GeneID; 20213589; -.
DR KEGG; hro:HELRODRAFT_64096; -.
DR CTD; 20213589; -.
DR eggNOG; KOG1922; Eukaryota.
DR eggNOG; KOG1923; Eukaryota.
DR HOGENOM; CLU_002356_1_0_1; -.
DR InParanoid; T1FXP1; -.
DR OMA; SINEHIC; -.
DR OrthoDB; 5485896at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IBA:GO_Central.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45725:SF1; DELPHILIN; 1.
DR PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 1..281
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 467..864
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 387..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 299..379
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 838..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 387..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..439
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 107690 MW; DF04A155ADC1112E CRC64;
VEQFFNAKGF DALINYFKVT TSKYSHDRIN EVVIGCLKNI MNCQEGRKAV LMHSDAVNVM
ALKSFPSENK NVRSRTLCIS ILSALCMVPG GHKKVIHAMT YAQTTVKDRT RFQVLLYDLD
VESNYADDYK SCIELKTAII AFINSLINYG PGEKSIEFRL HLRYEFLMLG IESIFDKLKL
YGNNIINKHI DFFELIRNKD EKEFVTLSSS KTRFDSKSVS SMFEALKQKY IVSPIYTNIL
SILYHLLLIQ SKSHKSTSTC HQWKLIDNIV QEISIQSKDG DTAATVGLLG DSVKSIISKM
IQEESVKETQ KRLVDAQKKT MDLKALLEKK EKECETKSEE KDMLLETLNQ MKIKLEKDAS
EYKQTISDLL IQIEQLKLSS FKKFENDNVP SNQDSNNHFS NTPTTPNAVP INSPDLIPSL
PELPPECPMP PPPPLPLSPP LPLSPPDCSI PPPPPPPSFI GLSTKPTKNC PQPTQPMKCF
NWTKIPEGKI SGTIWEKLDD SKIYCQLDLD ELEKNFTAYH KQDQNMDGEN KGALNRSAKI
LSLIDGRRSQ NCTIMLSKLK MSNYDLIQAV RNVDPNNELT KDMCEQLLKF TPTTEETQML
NEQAKEIDNM AKADRFLLEI SQVDHYESLL KCLYYKKKYN ERINDVVPRV TAVSSACHEV
TNSSSLMTVL EIILALGNFL NKGQRGNAYG FKLSSLTKIM DTKSSVNKKT SLLHYLVEIM
DSKFPDIKDL RNEMSDVKNA SKVVLPELES EINSLKNGLT DVEIETKYQQ EKRLIGQSVF
CQVMNEFLSV SSCRLFTLAD QLREMKNQYQ TVLKIYGEEL NIQPEEFFKH FDLFLDNMDE
ARNENLALKK LKEEEEKRAL REAELKAEKQ RRKSSLTDGT QTETGEFDMM IKTLMTGEAY
DGVKSKMKRN QVKKFYTAEK SSSNIPPSYS ASKMFSPQDK SHYK
//
