ID T1FXV7_HELRO Unreviewed; 1159 AA.
AC T1FXV7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO05942.1, ECO:0000313|EnsemblMetazoa:HelroP64508};
GN Name=20213655 {ECO:0000313|EnsemblMetazoa:HelroP64508};
GN ORFNames=HELRODRAFT_64508 {ECO:0000313|EMBL:ESO05942.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP64508, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05942.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP64508}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01000479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096324; ESO05942.1; -; Genomic_DNA.
DR RefSeq; XP_009015310.1; XM_009017062.1.
DR AlphaFoldDB; T1FXV7; -.
DR STRING; 6412.T1FXV7; -.
DR EnsemblMetazoa; HelroT64508; HelroP64508; HelroG64508.
DR GeneID; 20213655; -.
DR KEGG; hro:HELRODRAFT_64508; -.
DR CTD; 20213655; -.
DR eggNOG; KOG0921; Eukaryota.
DR HOGENOM; CLU_001832_1_2_1; -.
DR InParanoid; T1FXV7; -.
DR OMA; RFKCELR; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050684; P:regulation of mRNA processing; IBA:GO_Central.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 3..71
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 185..257
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 394..560
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 636..809
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 75..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1159 AA; 130436 MW; A8594CDD5CBA2C6D CRC64;
MKDIKDFLYS WCGKKKIVPA YEIRTTGNRQ RQRFLCECRL PGYSYVAVGN STSKKDAQTN
SARDMLQYLI RTGEIDPSQA PDLNETSEPM GRSQIRDLNR PQEATTRGCT TTTTTTTTTT
TYNITTITTA ATTITTTAAT TTTTAATAST TRTTATATTT TTAATATAEE ADFTADLHGS
WTMENSKSRL HQYLQTNKIK TDYKYSFVGP DHSRSFIAEM SFYLPSLRRN ISAREHGSNK
QVASKSCALS LVRQLFHLKL IEAFTGLKKS KEIELPPFTT KLNSDLEDEL NALLDEMQIS
INLVGWLLGL AGWFVNSNDV QAACIVSWSP PVPNWNPWVS CNIDEGPLAT ATMEDISGDL
LNTYTDKLNN DGAFIKSLND RKRLPIFNMR QQLIQTIRRH SVVLVRGETG SGKTTQVPQF
LLDDMIERGE GSMCNIVVTQ PRRISAISIS ERVAAERCEP LGQTCGYSVR FESCLPRPYG
SILYCTVGCL LRKLESGLRG VSHVVVDEIH ERDINTDFLL ILLRDMVQTF PDMRVVLMSA
TIDTTTFQEY FSDSCQLVEV SGRTYDVEEY FLEDVVEMLR FTPTPNLKKR RNNNNNKDDI
NDDDDENCNM YVSGSYSEHT KRAMSMMSEK EHDFELVEAL IKHISTKNIP GAILIFLSGW
NIIFTLHKYL SQHPIIGRSR YRILPLHSQI PREEQHKVFE PVPQGVTKII LSTNIAESSV
TIDDVVYVID FCKSKIKMFT SHNNMTNYAV VWCSRTNLEQ RKGRAGRVRP GFSYHLCSRE
RFKRLDQYTC PEILRSPLHE LCLSIKLLRL GPIGWFLSKA IQAPPIDAVI EAEALLREMK
ALDRNDDLTA LGRILARMPI EPRLGKMIIY ACVFRIADAA CIIASSSTFT EPFVVPMDRR
RLDWIHKNMA GDRFSDHCAL LNAFQMWNDA KNYGEMSEVN FCDAKSLSLS TLRMTNEAKN
QLCGILINAG FPEDCFTPVK FKFRGGDHNL DLLNTLLGIG FYPNICMHKD KRKVLTMGNK
PALIHKSSVN CSNRPIQYPI PFFVFSEKIR TRAVSCKQMS MYTPVQMLLF GARSVKFDGN
HIVLDSWINL AMDPVVAAKV AALRPLLEDL VVRATSDPES LEAGQGRGHE DLDGKLMRLV
GQLSNINCAT FGFVGPEGE
//
