ID T1FY95_HELRO Unreviewed; 451 AA.
AC T1FY95;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN Name=20213793 {ECO:0000313|EnsemblMetazoa:HelroP65555};
GN ORFNames=HELRODRAFT_65555 {ECO:0000313|EMBL:ESO02639.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP65555, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02639.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP65555}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMQM01000975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02639.1; -; Genomic_DNA.
DR RefSeq; XP_009020047.1; XM_009021799.1.
DR AlphaFoldDB; T1FY95; -.
DR STRING; 6412.T1FY95; -.
DR EnsemblMetazoa; HelroT65555; HelroP65555; HelroG65555.
DR GeneID; 20213793; -.
DR KEGG; hro:HELRODRAFT_65555; -.
DR CTD; 20213793; -.
DR eggNOG; KOG4206; Eukaryota.
DR HOGENOM; CLU_039888_2_1_1; -.
DR InParanoid; T1FY95; -.
DR OMA; CPFGPIT; -.
DR OrthoDB; 1331467at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR GO; GO:0030626; F:U12 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12238; RRM1_RBM40_like; 1.
DR CDD; cd12239; RRM2_RBM40_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034147; RBM40_RRM1.
DR InterPro; IPR045164; RBM41/RNPC3.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR16105:SF0; RRM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16105; UNCHARACTERIZED; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 4..79
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 363..446
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 198..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 51397 MW; 374DE368C9E845EF CRC64;
MSSKTLLIRH VPSKFTSNDC SDLFQRFGAK KVRYMGKEGK MKHTAFALFD SESEAKIAMN
HLHQLKLLDR RLVVEYSDKE FVEDLNLPAQ KLLDEFKRND TQVVEPSLGQ QIDSQLADYF
NFEYPINPNL RYSYPKPTVT ILTNIANALA SVPKFYTQVL HLMNKMNLPA PFGNLTITPP
IVDDSNVRLN VTERLSDESE IDSDSELTSN SRSTKKRKSL AEQDDLTRKK LKLQLAMEAQ
MQTLGTIHAK TATTKVSTEE VFEETDKINK SKKIGFKITN EDVGNVASTA NSQSTETVLP
TTEGFGKIVP TVNQVPKVIE VQDIEWGVDD FIPKDEIMKN RLEENEFHTL NVFKNYNPGE
KSSRLYLKNL AKSVTERDLH LIFGGFVNWS SQEERIMYDI RLMKEGRMKG QAFITFPSDF
QAEQALKSIN GYRIFGKPVA IYFARSAKPK H
//
