ID T1FYD7_HELRO Unreviewed; 777 AA.
AC T1FYD7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Bicarbonate transporter-like transmembrane domain-containing protein {ECO:0000259|Pfam:PF00955};
GN Name=20213835 {ECO:0000313|EnsemblMetazoa:HelroP65855};
GN ORFNames=HELRODRAFT_65855 {ECO:0000313|EMBL:ESO01913.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP65855, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01913.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP65855}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
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DR EMBL; AMQM01000749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO01913.1; -; Genomic_DNA.
DR RefSeq; XP_009019321.1; XM_009021073.1.
DR AlphaFoldDB; T1FYD7; -.
DR STRING; 6412.T1FYD7; -.
DR EnsemblMetazoa; HelroT65855; HelroP65855; HelroG65855.
DR GeneID; 20213835; -.
DR KEGG; hro:HELRODRAFT_65855; -.
DR CTD; 20213835; -.
DR eggNOG; KOG1172; Eukaryota.
DR HOGENOM; CLU_002289_6_0_1; -.
DR InParanoid; T1FYD7; -.
DR OMA; AIFHWIV; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:monoatomic anion transport; IEA:InterPro.
DR GO; GO:0050801; P:monoatomic ion homeostasis; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF82; SOLUTE CARRIER FAMILY 4 MEMBER 11; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..724
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
SQ SEQUENCE 777 AA; 87937 MW; 216DAF76D88B1FA7 CRC64;
MECIIWNSTL KIFSRLQKIP MKDFAAEIRA HLDVEQFLSQ AQLMLDVQEN DLKQILNEML
HHLMDHEESV SAFQEASRAL FTDATGQLGF IGLSKSIQCT CSSYGGSYDY DQSWICVLCT
AATVQKRHVA IARLRSPANL GRTCQEVWFI IMVVTSTKEA FINIKGTKNA LETGRTFATL
FADIDLRLRL LGARTEQEFK QVMWEHMKEL AEEQCEDNSK RKMSGDSNCK MVDPQVQNSS
RMCWIGRGIR EDLKRRLPHY LSDFKDGFVG QNTLHKTVST TFFLYFACIL PAIALGVLNY
NNTSGKIDVT KAIYSQTIGG LFFALMGGQP MVILLTTAPL ALYTKVIYNI CQEWGLDFMS
MFACIGLWNS FFLLIYAFTD ASKLMKWCTR STEEIFAIFI SLAFAFDAFK DVVSDFHENY
NSKACLQSSS SSSYYHTLTN DSIITNAIQS ALTSSLSSSS SPLSLFSENS LLYLLLMLGT
VWLGLSLYNF TKTPFLNASK RELLADCALP VSVILMSFFG SYVFREVNLK KFQVIDKGDL
FKLPRDMLNL TMALGFCLSL LFFMDQNTAS AIVNSPDNRL KKGPAYHWDL VVIAIINAIL
SFLGLPMVHG ALPHSPLHVR AMADKEDRVY QGRVHLKIVS VRETRVTGIL SHILIGLSVH
FIDKLQSIPR PVLDGLFLYL AITALHSNQM FERIMLLLTE QAAYPPNHYI RTVPQRKIHL
FTFIQLLQLA ILCGFGFAPV TYLKMVFPIL HLVMLPIRHK VVPHLFERKF LQSLDGH
//