ID T1FYR4_HELRO Unreviewed; 321 AA.
AC T1FYR4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=LIM domain-containing protein {ECO:0000256|PIRNR:PIRNR038003};
GN Name=20213962 {ECO:0000313|EnsemblMetazoa:HelroP66818};
GN ORFNames=HELRODRAFT_66818 {ECO:0000313|EMBL:ESN98990.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP66818, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98990.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP66818}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097143; ESN98990.1; -; Genomic_DNA.
DR RefSeq; XP_009022476.1; XM_009024228.1.
DR AlphaFoldDB; T1FYR4; -.
DR STRING; 6412.T1FYR4; -.
DR EnsemblMetazoa; HelroT66818; HelroP66818; HelroG66818.
DR GeneID; 20213962; -.
DR KEGG; hro:HELRODRAFT_66818; -.
DR CTD; 20213962; -.
DR eggNOG; KOG2272; Eukaryota.
DR HOGENOM; CLU_001357_0_0_1; -.
DR InParanoid; T1FYR4; -.
DR OMA; VCAQCFE; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0045216; P:cell-cell junction organization; IBA:GO_Central.
DR GO; GO:2001046; P:positive regulation of integrin-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR CDD; cd09331; LIM1_PINCH; 1.
DR CDD; cd09333; LIM3_PINCH; 1.
DR CDD; cd09334; LIM4_PINCH; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 5.
DR InterPro; IPR047944; LIMS1/2-like_LIM1.
DR InterPro; IPR047946; PINCH-1/2-like.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24210:SF0; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00412; LIM; 5.
DR PIRSF; PIRSF038003; PINCH; 1.
DR SMART; SM00132; LIM; 5.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR038003};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 4..65
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 67..124
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 187..246
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 321 AA; 37346 MW; 91828F771417978B CRC64;
MSLRVCARCH EDFDKEEEIV NSNGQIWHKK CFVCAQCFQQ FPDGIFFEFE GRKYCEHDFN
ILFAPCCGSC ENFIIGRVIK AMNLNWHPNC FVCQICSVPL ADTGFVKNGK RPLCRECNNK
EKVLGTGKFV CHKCHSIIEE KHIKFRGESY HPYHFNCHSC SIELNEEARE INNELYCLRC
HDKMGIPICG ACRRPIEERI VNALGKSWHV EHFVCAKCEK PFLGTRHYEK KGLAYCETHY
HQLFGNICFV CNCVIAGDVF TALSKAWCVD HFTCSVCDKK MSQKTKFFEM DLKPVCKLCY
EKFPGELKKR LKKAYDFQPK K
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