ID T1FZ69_HELRO Unreviewed; 4336 AA.
AC T1FZ69;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Dynein heavy chain 10, axonemal {ECO:0008006|Google:ProtNLM};
GN Name=20214117 {ECO:0000313|EnsemblMetazoa:HelroP67881};
GN ORFNames=HELRODRAFT_67881 {ECO:0000313|EMBL:ESN96268.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP67881, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96268.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP67881}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AMQM01001372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96268.1; -; Genomic_DNA.
DR RefSeq; XP_009025152.1; XM_009026904.1.
DR STRING; 6412.T1FZ69; -.
DR EnsemblMetazoa; HelroT67881; HelroP67881; HelroG67881.
DR GeneID; 20214117; -.
DR KEGG; hro:HELRODRAFT_67881; -.
DR CTD; 20214117; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_9_1_1; -.
DR InParanoid; T1FZ69; -.
DR OMA; MACCIAL; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 53..619
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1116..1520
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1656..1981
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2142..2273
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2503..2569
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2635..2895
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2908..3242
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3270..3490
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3737..3849
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3883..4028
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4036..4333
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2938..2993
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3124..3186
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4336 AA; 500038 MW; 904221641896DE90 CRC64;
MKRDVVATHF KNFQEAMRTT KEKLEGVLQL TVSNELKNIE LSESVDRSLL PLIEKMCITW
LSQLQDSLSA LDEKYFVGSS PLNELEYWKD RYTNLDLLSK QLKNPTVAYI INVQNKINGL
MTPTVERLES LLIEAKENNR FLSTCERHFK NIEMGANYQI VIESIVPLMK SLRLIWMISR
HYNNDERMIS LMEKIAKVLI DRVKKVNSFQ TLFMEGLDVV KSRTSNAETL LKLWKQAYLE
TRHFIETSGR GTRWEFDRKR LFQQTDYMAA ISHDINAAVH IIDEFNQLYE LNLFTVTIKP
SKIAEMKQTM ASLQNSFQTC KFDPFDSTNE RAWVFKMESF SKELFEFEVT SQLYIQDAFR
NIRSPVMGLQ LFKNLNMVLE RSSLTKMLNE KLKDISNSFF YQVNKTRQDF EDNFYNPPLF
KSQPPVAGTI NWQRFLFVRL KNTLISLLYD SDCLSIEEAD KLKDTYLTLC KEMKQYSQKK
YSEWYEKVDQ EMEQLLKSPV LAFPYFTQLQ KLEFSHRSTQ NQFKVNFDPY IFEVIMEAKY
LAGMGFNIPE SVKTAVLLEQ DFNERILLLK KFLNVFHEEI SKVNEVDFMV LEDHIKELFR
VVFSGMKRIN WRSAGVSDFV ERCHEQLEGF VSVMSQYKKN IKRIEDRLEN IIDANYFSDK
VNFKVGVVLD CKDYFDLVNA DREEITERLI QDYNDITSMV QHVEFVIWKS SSGKCSRLKH
FYLYYESRIL QALTAMVMTN LNTFICLLSG QKSLFQIHGV LYHPYLELNP SNVNILRYIS
QCAADCIFTT KLFPRWLNAS AIPVSLVKES SVYVYSFLND IALNPDIINL LHKIQSIADN
ALTTAKNTLK PWKRFEVVWQ SDKDLVVSEW IEQVLPKACN YDEVLWDLKN QLAEINSEVL
LFDVDFLQMN LSALAYAVKE HYITLFDLYT NELHLSARNA LVAFKTDCEK KLDEMSFKPT
TIEDLKSVLQ LLNEIFGTCV EKQLLAREIT EKYNVLEIYG IVVGDEEKLL LNNLDMFSYI
LIEKARFYSS KLKVVKKKFA ELALREADEF HQTLTEFVKR FYNSGPGIVD DLEVGLSLMR
EFNFEMYRLE QKRQDIGNSQ KLFDLPIVMY SDFFRVQKDI NYLESIYKIF KNYMSARSEW
DVIQWTDLNV NSIQDGIDSL LLQAKKLPKA VKEMQSFTIL ENCMKSFKDN LPIIVELKNE
AMRERHWKIL MNKTKIKFDT NINAFTLKNL FAMNLANYYD VVIETISDAI KEANIEKALK
EIEYTWSNLR FNIVKYHKNT LDKGHMIGSV DEINQLLDDQ TMQLQGMNAS RNVVPFLNSV
QSWEKQLSLI SEVIYSWVIA QRKWLYLDSI FLSGDIKVQL PEEARLFDKL DKAYMKIMKE
TALNPVVKIC CLTPGRLREF EELILGLDRC QKSLNEYLDS KRNAFPRFYF ISDDELLSII
GSTDPQSIQE HIIKIFDNVA SIKLQPSTHG KTYDVMGMIS AEGEQMPFKN KVVAEGKVEA
WINNVLTAMQ NSNRRITKEA IFYYCAEGRS RISWMMEYQG MVCLAGNQVW WTWEVEDVFQ
KAANGDKQAM KLYSKKLVQQ IDDLVLLIRK PMTANNRKKI NTVLMIDVHA RDIIEGFVRD
SILRSSDFQW ESQLRFYWDI YSDQLIVHQC SGKFLYGYEY MGLNGRLVIT PLTDRIYLTL
TQALSMKLGG APAGPAGTGK TETTKDLAKA LGLLCVVTNC GEGMDYKAIG KIFAGLCQSG
SWGCFDEFNR IEISVLSVIS SQLQTIRNAL LLTLTQFNFE GGIISLDHKV GIFITMNPGY
AGRTELPESI KALFRPVVCI VPDLQMICEI MLFSEGFLMA KVLAKKMTVL YKLASEQLSR
QYHYDFKLRA IKSVLVMAGE LKRASDAEED VVLMRALRDM NLPKFVFEDV PLFLGLIGDL
FPGLNCPRIQ YPELTEAIED VLKENKYIVL AHQVDKVVQL QETMLTRHTT MVVGPTCGGK
SVIINTLALA QTRMGVPTKL FTLNPKERSV VELYGVLDPV SRDWTDGLLS NVFREINKPT
DKVEKKYIVF DGDVDALWVE NMNSVMDDNK LLTLANGERI RLQKHCSMIF EVSDLQYAQP
STVSRCGMVY VDSKNLKYEP YWQKWLKEKF ELRQNLIEME VLNKLFIKYI PPCIDLIFEG
KMGNVRKDPL KTIIPLTNLN LVRQLTHMLD ALIEYEDIDF DVLECLFVEA LYWSLGAGLL
ENSRAQFDTY VKQITTLYVT ASDVAAGPGE LPGDNTIYEF IWDHQSNQWI RWTSKVPDYI
HDPNVKFNEI LVPTIDTVSM KWILSLFLKM EKPILFSGES GTSKTATITS FLKNLNSEEY
QVLGMNFSSR TTSLDCQKNI ENHTEKRTRD VFGPPVGKRL VIFVDDLNMP QIDPYGTQQP
IAMLKLLLGY SGIYDRGSAL NWKTLRDLDW IAAMGNPGGG RNHVDPRFIS LFSFAYMVFP
TEDSIFKIYS SILSGYTTGF ASEIRDSVEI VTHASMNLFT GVLKDLPPTP SKFHYIFSLR
DLSRIYSGLS LMTAGNFKTR NDLFRVWRHE CLRVFSDRLT NEVDQEIVVQ KIRNLLEINA
SAYIDMLLAD PIIYGDYINV ENDDFPRSYK ELESYESLKN LYNEIIDYSK NSSKISLVLF
DDALEHLNRI NRVLLLPKGH CLLMGLGNVG KFSLAKLAAC IAGLEIFTIE LARGYSEASF
KEDLKILYDK ICIQNLKVAF LFKDQYIVEE NFLELINNML TLGTVPSLFD DEETEKIMEA
FQRDLPGYEK APTKEIFWHN FAKRANTNLH IILSMAANNE ELPKRCRNFP GLVSNTNIDW
VFPWPSQALL AVATSFISDE TNIIPVNHQT DVIQIAIYVH FSAIQASVNF WEKQRRRNYI
SPKNYLDFLA TYIKLVKEQY SYINMQCDRL DGGIKKLLES AVQLNDFNAK LAVQKIAVNE
KTQSCQKLLT RIAQATAEAE AKQSLALIKS AQIEEQTKDI TREKEEAREA LSKAMPALES
AKQALDYIDR NDVTEIRSFA KPPKPVQTIG ECIVVLKGIK DVSWKSAKTL MTDPNFLKSL
KELDVDNIPI RNIHVVKYCL KEMNITVEEM RDKSRAGAGL MKFVQAVVGY CEVYKEVKPK
KEKVERLEKE FATTMHELEK ITSQLNQLQK TLDNLKHQYE TAMLDKKQLE DETDLMQRRI
VAADRLIKGL GSERIRWQKE LEDLYLQKGN VIGDCLLCAG FLTYTSPFTW QFRENLVYNS
WLQNIKELEI PLSEPFSLTK LLTNDVEISK WNSEGLPPDE LSVQNAILAT RSNRFPLCID
PQQQAMNWIK QREKGTSFKI SSFNEPDYIK HLELAVKYGS SFLFQDVDDY VDPLVYNILS
KTLIKQGAVQ GVMMGDKMID FDDNFRLYLN TKLPNPNYPA SIYAFATVIN FIVTFKGLEE
QLLGVIVKIE KNELEERREQ LIYETSTNKK LLKDLEDSLL RELAQSKGNM LDSVDLLTTL
ENTKLKSSEV AEKLRLGALT TDEIDRNRDI YRPVAKLGAI LFFVLGDLAT INVMYQYSLS
AYIKVFEYSL RRSLPDSRIA NRLKNISEAL LINVYNYGCT GIFEKHKLLF SLQIAVKLKL
DENSITEEEL DFLTKGNVSL EKSPLVNPFA WLPDDAWECL TLLPEVSPNN FENIISDIQS
SETDWKVWYD HDSPETLDFP MQYEETLSDF HRLMLLRCFR LDRLYCAISD FISDYMGEQF
ITPPIVSLST IHEQSSTTTP VIFILSVGSD PTSDLIKFAD SVNIKNTQLK ILSLGQGQEK
TAMSLITAAV THGHWLILQN CHLLIRFMRD LEKEFENFTK PHPDFRLWLT TEPVGDFPIS
VLQRSLKVVT EPPNGLKHNL QSTYVKLVSP VIEKFCAHPH YPSLLFVLSF FHAVVQERRK
YGKIGWNISY DFNDSDFIVC NTILQSSLQK VIDSSDEVIP WNSLKYLIGE VMYGGRAIDD
FDRRILNTYM NEYMGDFLLD PYQKFHFNIS EEFEYLLPTA TSKEEYLEYI EDLPLITSPE
VLGLHENAEI SYFLQAGQDI LDFMKMLQPK TKITDSSGSN REDIVSKLAQ DMLSKIPEEF
NIDNIRKNHA NNITPSIIVL LQELESFNKL SRKMINSLHT LRKAIAGEVG MDNDLDEISN
SLFFGVIPQL WRRLAPLTKK SLASWITFHL DRRRQYNEWA FDNEPVVMWL SGLHVPESYI
TALIQMTCRK NGWPLSKSTL FTKVMSEPII GDALDSISQG KMVTGLYLEG AGWDYQNCCL
VKQEHKKLST PMPIIKMIPI QRSKLRLANT LRTPVYVTSD RRDAMGVGLI FEADLPTKQH
LSHWILQGVC LVLNPE
//