ID T1FZJ7_HELRO Unreviewed; 1616 AA.
AC T1FZJ7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0008006|Google:ProtNLM};
GN Name=20214245 {ECO:0000313|EnsemblMetazoa:HelroP68810};
GN ORFNames=HELRODRAFT_68810 {ECO:0000313|EMBL:ESN94675.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP68810, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN94675.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP68810}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; AMQM01001710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097571; ESN94675.1; -; Genomic_DNA.
DR RefSeq; XP_009027206.1; XM_009028958.1.
DR STRING; 6412.T1FZJ7; -.
DR EnsemblMetazoa; HelroT68810; HelroP68810; HelroG68810.
DR GeneID; 20214245; -.
DR KEGG; hro:HELRODRAFT_68810; -.
DR CTD; 20214245; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000540_0_2_1; -.
DR InParanoid; T1FZJ7; -.
DR OMA; CEFANER; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 48..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 906..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1020..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1129..1148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1154..1178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1209..1238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1313..1337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1507..1528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1534..1558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..336
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 443..679
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 775..1048
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1095..1347
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1357..1410
FT /note="Voltage-dependent L-type calcium channel IQ-
FT associated"
FT /evidence="ECO:0000259|Pfam:PF16905"
FT DOMAIN 1420..1497
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|Pfam:PF08763"
FT REGION 684..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 624
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1616 AA; 185043 MW; 07B3DB15B66B2850 CRC64;
MSWKKKLIKF CANITFPCFD KSTTRSLFIF SETNILRRFC LFLVHNKFFE YFILLAIVAN
CLVLALDEYL PDSDRTDMSL KLEYANPYFL IIFTAEAVLK IIAHGLILHT DSYLRSLWNI
LDFIIVTAGL LAQLNSLFNQ PGIRSLRVLR PIKIVTGFES LQVVLKSIIY AMKPLLQIGF
LVLFAVVIFA IIGLEFYCGV LHKSCYKDEK REVVYEENEE PVACAFTSIL TNPNATVSSS
IIGGGYTCPV GYECREWWEG PFSGLCNFDN IYASILTVFV VLTMAGWTLN MYYLDDAVGR
LFNWLYFVPI IIFGALFMLN LVLGVLSCEF ANERQRVENR KDFLKLKKQK VLDEILENYM
DWICRAEEMI LNEGSTTSEE RLRILEARRT STFVRLKGAD DRKIMTKEEE DKIRATRATN
CFQKVWRKQR LFRLKIKKVI KSQAFYWLVI GLVFVNTALI SAEHHHEPAW LNDLLTYSEY
VFLATFLFEM FLKMYALGLR TYFASMFNKF DFFVLIASTI EVVLQMIYEN LSFGFSSLRA
TRLLRIFKIT RYWRALRNLS LSLINSIKSI MSLLFLLFLF MVIFALLGMQ YFGGRFNFDE
GRPKANFDTF SSALLTVFQI LTGEDWNKVM YNGMRCQGGF KTSGVLASLY FLVLMILGSY
TLLNVFLAIA VDNLAKADEL TSMENAEEQG ENHDDEEEDN DRRESVVIVS IPPNVEISSR
HGSRASGAKE GSRVEEEEDE EDIYAVKPIL PYTSLFIFSS TNPIRKFAHF FATMKYFDYF
IMVIILFSCI QLAMEDPVSY KSHFNDILYV IDYSFTAIFT VEASLKILDK GLVLHKGAYC
RDMWNILDLF IVVCAISDIA FADSNVNLGT IKSLRVLRVL RPLKTINRIA KLKAVFNGLV
MAVRKVFVIM VLYVLFQIIF AIIAVQLFMG RFYRCSDLSK LTAEECNGEY LVFEDSGVKA
NTREWTHYDL YFDNIGASLL TLFVVQTRSG WPEILEHAMD SSLPDHGPVP ENNNIMAIFF
IIYFLVFPFF FVNLFVALIV ITFQAQGEKD LEEMNLDKNQ KNCLEFVVNS KPIDCYMPNV
SRKVRLAAWK FVMSKPFDFI MSALICLNTV TLMMKFYNQP AWYDNVLSYL NIFFTCAFTI
EFLIKLFAYG FKNYFIQAWN VFDFITVIGS IIDISVYYTE GNLKTLGFLK LFRAARLVKL
LKQSTSIRML LWTFLQAIKA LPYVLLLIGL LFFVYAVIGM QILGTIKLDV DSEISRHANF
QNFPNALLLL FRCSTLDNWD NILSSTTSGQ PCEPTSLEPG ADPDTNKCGT DFAILYFVSF
NFLTAFMMLN LFIAVIMDNF DYLTRDSSIL GPHHLDEYLH RWAVYDPTAS SYISYSDAYK
LLKELEPPVG FGKKCPWKLA YRKLIRMNMP INEFGKVHFK TTMFALVRES LGIKMGDAEV
MDQLDWELRN ILLDLFDLKP ADLDILLPPI EEYVGKKVSV GKVYASMLLV DAWKQFKLSF
NPNLEPIVSE AIIIIIIIII IIIIIIIIVI IIIIIIIIII IIIIIIIIVI VIIIIIIISS
SRSSISSSFS SSCCCSSSSR SSISSSFRSS SRSSISSSFS SSSSSSRGCS SSRSVH
//
