ID T1FZU6_HELRO Unreviewed; 711 AA.
AC T1FZU6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Vesicle tethering protein Uso1/P115-like head domain-containing protein {ECO:0000259|Pfam:PF04869};
GN Name=20214344 {ECO:0000313|EnsemblMetazoa:HelroP69392};
GN ORFNames=HELRODRAFT_69392 {ECO:0000313|EMBL:ESN92897.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP69392, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92897.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP69392}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097639; ESN92897.1; -; Genomic_DNA.
DR RefSeq; XP_009028821.1; XM_009030573.1.
DR AlphaFoldDB; T1FZU6; -.
DR STRING; 6412.T1FZU6; -.
DR EnsemblMetazoa; HelroT69392; HelroP69392; HelroG69392.
DR GeneID; 20214344; -.
DR KEGG; hro:HELRODRAFT_69392; -.
DR CTD; 20214344; -.
DR eggNOG; KOG0946; Eukaryota.
DR HOGENOM; CLU_006318_2_1_1; -.
DR InParanoid; T1FZU6; -.
DR OMA; WLWEDPK; -.
DR OrthoDB; 1774at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR GO; GO:0005795; C:Golgi stack; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0048211; P:Golgi vesicle docking; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0061025; P:membrane fusion; IBA:GO_Central.
DR GO; GO:0045056; P:transcytosis; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR041209; P115_Arm_rpt.
DR InterPro; IPR006953; Vesicle_Uso1_P115_head.
DR PANTHER; PTHR10013; GENERAL VESICULAR TRANSPORT FACTOR P115; 1.
DR PANTHER; PTHR10013:SF0; GENERAL VESICULAR TRANSPORT FACTOR P115; 1.
DR Pfam; PF18770; Arm_vescicular; 1.
DR Pfam; PF04869; Uso1_p115_head; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 358..641
FT /note="Vesicle tethering protein Uso1/P115-like head"
FT /evidence="ECO:0000259|Pfam:PF04869"
SQ SEQUENCE 711 AA; 80519 MW; E5F1E66416225B6F CRC64;
MDLFRKYLAG PQAGLEPTEA ETVERLTDRV NSSTLLEDRR DAVRALKSLS KKFRYEVGTK
SMNTLIAVMQ TDRTDLEILG YTLDALCNIM SCDVDDESLL SLLASNIYEE SSGFKSNGKL
TLLFSEMFIK DTNNVSLLLS LLQEYDYHIL LPTIHLLTVL LQNKTRDVQE IILTNPMGIS
KMMDLLADSR EVVRNENMLL LYELTKGNTN IQKIVAFENA FEKLFEIIRD EGGSDGGVVV
EDCLLVLLNL LRNNISNQNF LKEGSFIQRL PSYFDINDNS EHCITWPLQK TMNVCNMLKL
IRLLVSPNNP LQHITSCQIL MHNCGLLNNL SKMVLAVGIP VDALIETINA VAEIIRGNQQ
NQDFLASVLA PSVPPRSAIV VLLMSMLSDS RPFQLRCSVL YCFQSFLYKN ELGQSQIIKT
LLPSTSEVNQ ISSGQLLCTG LFNNDPLSTW FSAISLLHSI INNQDQKEQL LRVQLATSLG
NTPVTLIQQC ANMLSMGLRF QTRVGLLQLL CHWLADCSNG VTHFLLESSN VPYLISHVSS
SEGDENEMII RGLCAFLLGI LVLFNNNQVH SFHKSDLRQI IEKRIGVEQY ADMLSQVSKH
ESYSKASKAP NIMCNEPSEV IFDFEFTRLF KKLENEVLKA VTTTNDTDHD KNVQHDNIVE
QYKLIIREQV NINLYMNAQM HLFIFCLYIH LKSNLFNYTF RIATTELLII N
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