ID T1FZV9_HELRO Unreviewed; 367 AA.
AC T1FZV9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=HRO-DL {ECO:0000313|EnsemblMetazoa:HelroP69490};
GN Name=20214357 {ECO:0000313|EnsemblMetazoa:HelroP69490};
GN ORFNames=HELRODRAFT_69490 {ECO:0000313|EMBL:ESN92722.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP69490, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92722.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP69490}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01001846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01001847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097639; ESN92722.1; -; Genomic_DNA.
DR RefSeq; XP_009028834.1; XM_009030586.1.
DR AlphaFoldDB; T1FZV9; -.
DR STRING; 6412.T1FZV9; -.
DR EnsemblMetazoa; HelroT69490; HelroP69490; HelroG69490.
DR GeneID; 20214357; -.
DR KEGG; hro:HELRODRAFT_69490; -.
DR CTD; 20214357; -.
DR eggNOG; ENOG502QQS6; Eukaryota.
DR HOGENOM; CLU_004343_3_0_1; -.
DR InParanoid; T1FZV9; -.
DR OMA; GVCTVKV; -.
DR OrthoDB; 1059550at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0038061; P:non-canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF20; DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 8..184
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
SQ SEQUENCE 367 AA; 41746 MW; 22C4876C5F4B8B58 CRC64;
MVQETPARKD PCVSIDEQPK QRGLRFRYKC EGRSAGSIPG EHSTSDRKTY PSIKIHNFEG
PAAIVVVSCV TKDKPYYPHP HNLVGQDCKD GVCTVKVKNP SSVITFPNIG IQCCKRHDVE
DNLKIREKIR VDPYSTGYPS ANNNIDLNSV RLCFQVFLPD ANKKFTHIVP PIVSQPIIDK
KSVHDLVICR LSRQSGYAVG GDEVFLLCEK INKDDIQVRF FEETDDREVW EGNGDFAPND
VHRQYAIVFK TPPYRNPDIQ EPVTVFVQLR RPSDDEVGDP KPFQYIPQDP DPYGLNMKRK
KKELNISDPC QNQIPRMVMD ESSPGASACR MNIRNKLKKK AEEGLQRRDS TSMLLMLLIL
MLQILCC
//
