ID T1G0J8_HELRO Unreviewed; 518 AA.
AC T1G0J8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=BOS complex subunit NCLN {ECO:0000256|ARBA:ARBA00034873};
DE AltName: Full=Nicalin {ECO:0000256|ARBA:ARBA00041615};
GN Name=20214596 {ECO:0000313|EnsemblMetazoa:HelroP71336};
GN ORFNames=HELRODRAFT_71336 {ECO:0000313|EMBL:ESO11566.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP71336, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO11566.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP71336}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; AMQM01002465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095812; ESO11566.1; -; Genomic_DNA.
DR RefSeq; XP_009010054.1; XM_009011806.1.
DR AlphaFoldDB; T1G0J8; -.
DR STRING; 6412.T1G0J8; -.
DR EnsemblMetazoa; HelroT71336; HelroP71336; HelroG71336.
DR GeneID; 20214596; -.
DR KEGG; hro:HELRODRAFT_71336; -.
DR CTD; 20214596; -.
DR eggNOG; KOG2526; Eukaryota.
DR HOGENOM; CLU_034102_2_0_1; -.
DR InParanoid; T1G0J8; -.
DR OMA; GVKSILH; -.
DR OrthoDB; 458841at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR CDD; cd03882; M28_nicalin_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF0; NICALIN; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..518
FT /note="BOS complex subunit NCLN"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010981084"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..325
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 518 AA; 58274 MW; 64FD34CF7FFB13AE CRC64;
MFRNSFPFSF LFFVPILFLI SPVCPASDFA VYRMQQFDLQ GVSHGCRNAI INVEARPITA
SVYTRKCVVS KLKELAFSKY KEILQQNANG LLVLLPRTFD QISREDEEHL IELEHQLLSD
ETQLPVYFAY EDDKLLNIYE DLKSFGNADS AESALEAIVR SSNLYGFQFI INGPQSKALN
DFEIVNLQGK LIGHGLEEQL PTVLVVAYYD AIGVAPSLAR GSNSNGSGVV AILELIRLFS
KLYSHSKSHP KMNLQFLLTG AGKLNYQGTK RWLEDHSEGL FVCMFLSQFK AVICIDSIGS
GPGLFAHVSK PPKEGSFADL IIKVCFAARL FEMIHKKINL AERHLSWEHE RFSINKLYAF
TVSSFKSPRD MRLRSITDTM DKLDVEGLSR NIRIIADGLA GQIFNLSNPG SDIFVDHLSV
NKELVSSWLE HISSVPRSAQ LLKKDSPLIS TFEGWFSKHL RSVKRHTFKA DKREPEFVFY
TGAEYSLGVY SVKPAVFDLI LAVGIALYLG LLYLISQV
//
