ID T1G0S0_HELRO Unreviewed; 448 AA.
AC T1G0S0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA polymerase delta subunit 2 {ECO:0008006|Google:ProtNLM};
GN Name=20214668 {ECO:0000313|EnsemblMetazoa:HelroP71825};
GN ORFNames=HELRODRAFT_71825 {ECO:0000313|EMBL:ESO11643.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP71825, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO11643.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP71825}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA polymerase delta/II small subunit
CC family. {ECO:0000256|ARBA:ARBA00006035}.
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DR EMBL; AMQM01002496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095812; ESO11643.1; -; Genomic_DNA.
DR RefSeq; XP_009010131.1; XM_009011883.1.
DR AlphaFoldDB; T1G0S0; -.
DR STRING; 6412.T1G0S0; -.
DR EnsemblMetazoa; HelroT71825; HelroP71825; HelroG71825.
DR GeneID; 20214668; -.
DR KEGG; hro:HELRODRAFT_71825; -.
DR CTD; 20214668; -.
DR eggNOG; KOG2732; Eukaryota.
DR HOGENOM; CLU_021763_0_0_1; -.
DR InParanoid; T1G0S0; -.
DR OMA; HCILIGT; -.
DR OrthoDB; 1604at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0043625; C:delta DNA polymerase complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IBA:GO_Central.
DR Gene3D; 3.60.21.50; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR040663; DNA_pol_D_N.
DR InterPro; IPR024826; DNA_pol_delta/II_ssu.
DR PANTHER; PTHR10416; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR PANTHER; PTHR10416:SF0; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR Pfam; PF18018; DNA_pol_D_N; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 32..160
FT /note="DNA polymerase delta subunit OB-fold"
FT /evidence="ECO:0000259|Pfam:PF18018"
FT DOMAIN 181..406
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 448 AA; 50754 MW; DE2E77119CB2CB77 CRC64;
MAEDECFKQR LSHVYSNESE RFQLKDRNYS RQYAHIYASR LEHNKSYLEE KCRRTWGCDI
PLKKISELVA DEKCAIIGTL FKQMIYKPNI LKEISEENQL EPQPIREKYT DSSDVLILED
DLQRILLVGN VESMKAITGV TAAILGCQDS NSGKFQVEDI IYKDLNPNIR SELNCNKESY
VVLLSGLEIG GDDKDAAELL MSVQLLIDLL NGSIGDEDIE NKMSKVLRVI IAGNSLSSKI
IEKDIISHGK HKKRHNRQND NEEEKESRDA IDKLDNFLFQ LSINAYVDLM PGPTDPTTFT
LPQKPIHRCL LPKSGALSTL NPVSNPYECK IEGYNFLGTS GQPVKDVVRI TEYEDELEVL
EGMLKFGHLA PTAPDTLGCY PFEEADPFII DVCPDVFFAG NCKKFDWKKY ENVSEKHTLL
ITIPSFKVTK TAVLLNLYDL TCSPISLP
//
