ID T1G1L4_HELRO Unreviewed; 452 AA.
AC T1G1L4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 28-JUN-2023, entry version 34.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=20214962 {ECO:0000313|EnsemblMetazoa:HelroP74042};
GN ORFNames=HELRODRAFT_74042 {ECO:0000313|EMBL:ESO08819.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP74042, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08819.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP74042}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; AMQM01003074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096023; ESO08819.1; -; Genomic_DNA.
DR RefSeq; XP_009012841.1; XM_009014593.1.
DR AlphaFoldDB; T1G1L4; -.
DR EnsemblMetazoa; HelroT74042; HelroP74042; HelroG74042.
DR GeneID; 20214962; -.
DR KEGG; hro:HELRODRAFT_74042; -.
DR CTD; 20214962; -.
DR eggNOG; KOG2514; Eukaryota.
DR HOGENOM; CLU_006685_3_0_1; -.
DR InParanoid; T1G1L4; -.
DR OMA; WISTLMA; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007632; Anoctamin.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF84; ANOCTAMIN; 1.
DR Pfam; PF04547; Anoctamin; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 38..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 159..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 264..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 314..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
SQ SEQUENCE 452 AA; 52178 MW; EDE5E7E7E56D8490 CRC64;
KIRQSQKLNE HWVKMKNIFY LQPYNEIRSY FGEQFTFYFA WMGLYTASLF AAALAGLACF
IYGLASFATI DDNVKEICDE TKAPGNYTMC PKCDFRCNYT KLSGSCNNAK FSRVFDNEAT
LACAIFICVW AICFMELWKR RQLALQHEWN VTNFEADELS MVVIAIFAVL VYRLALAHKT
RTSYEDSFIF KIVVFQCINN YGSIIYIAFF KGSFVDRPGF DKLYMFSKYR QDECEDTGCF
SELTIQLIVV MIGKQFLNAL IEMLAPLVVA IIIIIIIIII IIIIIIIIVV VWERDLDLEC
HPPISMFGEY LEMVIQYGFV TLFVVAFPLA PLFAFLNNII EIRLDAYKMV KLFRRCAALK
AQDIGAWEIS LQMISYMAVI SNAFIIAWTS DFIPKAVYKW NADTRSLSGY MNWTLAPFNV
SEFKANQRPD VSIYPEAANV TQCMYELIMF VY
//