ID T1G244_HELRO Unreviewed; 418 AA.
AC T1G244;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 9 {ECO:0000256|ARBA:ARBA00030445};
GN Name=20215142 {ECO:0000313|EnsemblMetazoa:HelroP75380};
GN ORFNames=HELRODRAFT_75380 {ECO:0000313|EMBL:ESO08032.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP75380, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08032.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP75380}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tubulin--tyrosine ligase family.
CC {ECO:0000256|ARBA:ARBA00006820}.
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DR EMBL; AMQM01003373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096134; ESO08032.1; -; Genomic_DNA.
DR RefSeq; XP_009013821.1; XM_009015573.1.
DR AlphaFoldDB; T1G244; -.
DR STRING; 6412.T1G244; -.
DR EnsemblMetazoa; HelroT75380; HelroP75380; HelroG75380.
DR GeneID; 20215142; -.
DR KEGG; hro:HELRODRAFT_75380; -.
DR CTD; 20215142; -.
DR eggNOG; KOG2157; Eukaryota.
DR HOGENOM; CLU_010131_0_1_1; -.
DR InParanoid; T1G244; -.
DR OMA; IWIMKPP; -.
DR OrthoDB; 7265at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF39; TUBULIN POLYGLUTAMYLASE TTLL9-RELATED; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
SQ SEQUENCE 418 AA; 49830 MW; A6FC437499A7D940 CRC64;
MQNFKFKHTH CVTFNTSDRP IRFKCFIQNT ILDVLRNRGW QEVIGEGEWD FYWCDVGWMK
EYFDHFFLEE QTKICHFRNH YELTRKNLMV KNLKRYRKQI EKEFGKVEAQ KCDFFPMTFE
LPTEYHMFVE EFKKSPGQIW IMKPVAKSQG KGIFLFRKLK DIVDWKKTSV DYSPPVKEPV
EAYVVQRYID DPYLIGGKKF DLRIYVLVTS YTPLKVWLYR EGFARLSNTR FSLDSITDTY
IHLTNVAVQK TAPDYDSEKG SKWSVQKLRL FMTFKYGKEK TNECFHMMDN MIIHSLLSVQ
KVMVQDKHCF ELYGYDILLD VNLKPWLLEI NASPSLQASN QEDYDLKFRM LDDVLNVIDL
ENRLTGNERN VGGFDMMWND GPIYAESSLA PEPQQLYFNS FPGLIDWLIH WLIGWLIN
//
