ID T1G2Q2_HELRO Unreviewed; 431 AA.
AC T1G2Q2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Orc1-like AAA ATPase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20215350 {ECO:0000313|EnsemblMetazoa:HelroP76855};
GN ORFNames=HELRODRAFT_76855 {ECO:0000313|EMBL:ESO06990.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP76855, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO06990.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP76855}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC5 family.
CC {ECO:0000256|ARBA:ARBA00006269}.
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DR EMBL; AMQM01003752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01003753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096275; ESO06990.1; -; Genomic_DNA.
DR RefSeq; XP_009015086.1; XM_009016838.1.
DR AlphaFoldDB; T1G2Q2; -.
DR STRING; 6412.T1G2Q2; -.
DR EnsemblMetazoa; HelroT76855; HelroP76855; HelroG76855.
DR GeneID; 20215350; -.
DR KEGG; hro:HELRODRAFT_76855; -.
DR CTD; 20215350; -.
DR eggNOG; KOG2543; Eukaryota.
DR HOGENOM; CLU_028223_0_1_1; -.
DR InParanoid; T1G2Q2; -.
DR OMA; QLRRWHG; -.
DR OrthoDB; 469431at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR020796; ORC5.
DR InterPro; IPR047088; ORC5_C.
DR InterPro; IPR048866; ORC5_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12705; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12705:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14630; ORC5_C; 1.
DR Pfam; PF21639; ORC5_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 7..143
FT /note="Orc1-like AAA ATPase"
FT /evidence="ECO:0000259|Pfam:PF13191"
FT DOMAIN 198..264
FT /note="ORC5 lid"
FT /evidence="ECO:0000259|Pfam:PF21639"
FT DOMAIN 295..427
FT /note="Origin recognition complex subunit 5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14630"
SQ SEQUENCE 431 AA; 49688 MW; F24D5907BD58D3DC CRC64;
MELENLLPCR SKQIDLICAY LDEVVVCFLP SMFVYGLPAT GKSSVIKCLV PYLKHRYINV
NCIECYTPRL IYECILGQLD PSFSGRCDNP SKFVDMLKET IITTCGSDHS IYIHFEKCER
LREVHPLMLP MFLKLQELVN FCVFLIHFVD VVVGVVSYKK NCFFEKIKLK QKNQKTNIDE
LLKILCHDTP ANVPHSTYEN FINLLLDVFH MVCRNLTELR YLAHVNLDKY LEPVHKGEAN
YGDTVKLWKN IEPHLKRAMQ TVFLREVSGE QWMKMQQLSS ESTSASSSTR STIEIPVYTK
YLLIAAYLAS YNPAKLDKRF FMKNAGKTSK RLKNAIKKKE ERTSCHLLGP KFFPLDRMMA
IFYSIVEEKV VPTANTFSQI SSLVSLGLLS QSSMVDQLDG QKYKCLVTLE QIKSVAKSVG
FEIMRYLYDF I
//
