ID T1G3H0_HELRO Unreviewed; 82 AA.
AC T1G3H0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Transcription factor COE helix-loop-helix domain-containing protein {ECO:0000259|Pfam:PF16423};
GN Name=20215618 {ECO:0000313|EnsemblMetazoa:HelroP78894};
GN ORFNames=HELRODRAFT_78894 {ECO:0000313|EMBL:ESO04580.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP78894, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04580.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP78894}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004489}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000256|RuleBase:RU004489}.
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DR EMBL; AMQM01004123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096457; ESO04580.1; -; Genomic_DNA.
DR RefSeq; XP_009017159.1; XM_009018911.1.
DR AlphaFoldDB; T1G3H0; -.
DR STRING; 6412.T1G3H0; -.
DR EnsemblMetazoa; HelroT78894; HelroP78894; HelroG78894.
DR GeneID; 20215618; -.
DR KEGG; hro:HELRODRAFT_78894; -.
DR CTD; 20215618; -.
DR eggNOG; KOG3836; Eukaryota.
DR HOGENOM; CLU_2564943_0_0_1; -.
DR InParanoid; T1G3H0; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.287.4280; -; 1.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR003523; Transcription_factor_COE.
DR PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR PANTHER; PTHR10747:SF38; TRANSCRIPTION FACTOR COLLIER; 1.
DR Pfam; PF16423; COE1_HLH; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU004489};
KW DNA-binding {ECO:0000256|RuleBase:RU004489};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU004489};
KW Nucleus {ECO:0000256|RuleBase:RU004489};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transcription {ECO:0000256|RuleBase:RU004489};
KW Transcription regulation {ECO:0000256|RuleBase:RU004489};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU004489};
KW Zinc-finger {ECO:0000256|RuleBase:RU004489}.
FT TRANSMEM 34..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..29
FT /note="Transcription factor COE helix-loop-helix"
FT /evidence="ECO:0000259|Pfam:PF16423"
SQ SEQUENCE 82 AA; 9353 MW; FF532F7A8A435675 CRC64;
LSEPTIDYGF QRLMKLVPRH PGDPERLPKV CHCVYVLACV CVVCVLCVCV YVCVLCVCVC
VRTYVSEKKC LLMNIRIHYC IV
//
