ID T1G4D2_HELRO Unreviewed; 277 AA.
AC T1G4D2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Tropomyosin {ECO:0008006|Google:ProtNLM};
GN Name=20215930 {ECO:0000313|EnsemblMetazoa:HelroP81331};
GN ORFNames=HELRODRAFT_81331 {ECO:0000313|EMBL:ESO01534.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP81331, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01534.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP81331}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction. {ECO:0000256|ARBA:ARBA00002987}.
CC -!- SIMILARITY: Belongs to the tropomyosin family.
CC {ECO:0000256|ARBA:ARBA00009036}.
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DR EMBL; AMQM01004928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01004929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096743; ESO01534.1; -; Genomic_DNA.
DR RefSeq; XP_009020188.1; XM_009021940.1.
DR AlphaFoldDB; T1G4D2; -.
DR STRING; 6412.T1G4D2; -.
DR EnsemblMetazoa; HelroT81331; HelroP81331; HelroG81331.
DR GeneID; 20215930; -.
DR KEGG; hro:HELRODRAFT_81331; -.
DR CTD; 20215930; -.
DR eggNOG; KOG1003; Eukaryota.
DR HOGENOM; CLU_055027_0_2_1; -.
DR InParanoid; T1G4D2; -.
DR OMA; QMEDELM; -.
DR OrthoDB; 2917119at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR InterPro; IPR000533; Tropomyosin.
DR PANTHER; PTHR19269; TROPOMYOSIN; 1.
DR PANTHER; PTHR19269:SF45; TROPOMYOSIN-1, ISOFORMS 33_34; 1.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT COILED 57..147
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 176..255
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 277 AA; 31703 MW; 3E6465943F6835F0 CRC64;
MTAIKKKMHG MKTLKESVFD EVDQLDQKLL EQKAIYEKVY EEILQLNKRI VQIQTDLGVV
QQNAQEATEK LDATTKQLTT AEAEMVSLGK TVRSLEEDYE STENRLLQTT TKLEQAAKSF
EESDRGRKVL ENRIAIDEER MVILEKELEV TILFGEDADR KYEETARKLA ITEVDLERSE
GRVALAEAKI IELEDELKVV GNNFKSLEIV QQEAKTYELT IQNLTDSLKD AENRAILAER
AVTMLQKEVD RLEGNEKDKF RLVLGELDST ITELTGF
//
