ID T1G4J2_HELRO Unreviewed; 318 AA.
AC T1G4J2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Phosducin thioredoxin-like domain-containing protein {ECO:0000259|Pfam:PF02114};
GN Name=20215990 {ECO:0000313|EnsemblMetazoa:HelroP81825};
GN ORFNames=HELRODRAFT_81825 {ECO:0000313|EMBL:ESO01233.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP81825, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01233.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP81825}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the phosducin family.
CC {ECO:0000256|ARBA:ARBA00009686}.
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DR EMBL; AMQM01005028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096785; ESO01233.1; -; Genomic_DNA.
DR RefSeq; XP_009020469.1; XM_009022221.1.
DR AlphaFoldDB; T1G4J2; -.
DR STRING; 6412.T1G4J2; -.
DR EnsemblMetazoa; HelroT81825; HelroP81825; HelroG81825.
DR GeneID; 20215990; -.
DR KEGG; hro:HELRODRAFT_81825; -.
DR CTD; 20215990; -.
DR eggNOG; KOG3171; Eukaryota.
DR HOGENOM; CLU_085598_0_0_1; -.
DR InParanoid; T1G4J2; -.
DR OMA; GIIEMMP; -.
DR OrthoDB; 2912029at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd02987; Phd_like_Phd; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.10.168.10; Phosducin, domain 2; 1.
DR InterPro; IPR001200; Phosducin.
DR InterPro; IPR023196; Phosducin_N_dom_sf.
DR InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR46052; PHOSDUCIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR46052:SF1; PHOSDUCIN-LIKE PROTEIN; 1.
DR Pfam; PF02114; Phosducin; 1.
DR PRINTS; PR00677; PHOSDUCIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 51..252
FT /note="Phosducin thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF02114"
FT REGION 19..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 36438 MW; 9E4EA90E6EF25915 CRC64;
MALSFDDKIL GEKTDYYCSS SEDEKYDSCD DDDNECGHSN QNHKSSSKSS TKMPTTGPKG
VLEDWRRYKQ LETERRDENE KERLALAKKL STTCRTIAKD LEYLEEIEDH LDDFDEEFMK
EYRAKRIESM RNAVVKCPQF GKVVHLNKQT FLEAIDKEDA CTIVVVHIYK KGVTACETMN
KCIDELSTAY PDVKFCKIET SHIQMSLNFS LAGVPALLVY KKGELVGNFV RLSDEFGDEF
FPNDVASFLV ELVSRYTRLR TYIHARTHTH VHSRTHLLTK TGMACYQITC TTAAEIRAFE
RALLNTATMT TTMTVTMI
//
