ID T1G4N7_HELRO Unreviewed; 744 AA.
AC T1G4N7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=20216035 {ECO:0000313|EnsemblMetazoa:HelroP82157};
GN ORFNames=HELRODRAFT_82157 {ECO:0000313|EMBL:ESO01448.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP82157, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01448.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP82157}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR EMBL; AMQM01005115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096785; ESO01448.1; -; Genomic_DNA.
DR RefSeq; XP_009020684.1; XM_009022436.1.
DR AlphaFoldDB; T1G4N7; -.
DR STRING; 6412.T1G4N7; -.
DR EnsemblMetazoa; HelroT82157; HelroP82157; HelroG82157.
DR GeneID; 20216035; -.
DR KEGG; hro:HELRODRAFT_82157; -.
DR CTD; 20216035; -.
DR eggNOG; KOG0447; Eukaryota.
DR HOGENOM; CLU_012302_0_1_1; -.
DR InParanoid; T1G4N7; -.
DR OMA; XIQQIIE; -.
DR OrthoDB; 48011at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 60..336
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 1..28
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 679..742
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 744 AA; 86319 MW; DC8A64AA523E7AA5 CRC64;
QIRFQKEIEK LEKENRELKK SLLLKEKDGL HKKKIKRSLI DMYSEVLDSL SDYDMTYNVQ
DQLPRVVVIG DQSAGKTSVL EMIVQARIFP RGSGEMMTKS PVQVTMSEGP YHVARLKDDA
KEYDLTKESD LDSLRREIER RMKSSLRKDQ TVSQETVSLS VKGPGLQRMV LVDLPGVIST
VTTDMADDTR EQIKKMCQHH MSNPNSIILC IQDGSLDAER SNVTDLVSSM DPSGRRTIFV
LTKVDLAESM LHNPDRIRKI LEGKLFPMKA MGYFAVVTGK GNSNDSIQKI KDYEERFFKQ
SKLFKGGVLR AHQMGTMNLC LAVSQCFWQM VRQSVEQQAD AFKATKFNLE TEWKNTYPKF
REMDREELYE KARGDILDEV VNLSNISAMK WEEVIAENLW SEVSTHFFEN IYLPAAHAEN
AGIFNTAIDI KLKQWADKIL PKKSIDVARE TLLEEFLNLL TSSSAAATAV AASNDNDVFH
DLKKEIVEEL KKRLKWDQQA INSLRVIQMN TLEDRSVHNR QQWDDAIVFM RKVLLNKKSQ
GEHVMRDMLG PSFWQKYMYW MSRSEEQSLR RSVKNELDKM LLGGNLMHSS KLGKDELIAV
RKNLEAQSID VQDDFIEKTW HIMYRQHFLA RRLITAANCQ KGFYYYQQGF QDNSVDCSDV
VLFWRVERML QATSKALRQQ IMNNETRRLE QDVKQVLDEI YDDKAKMKQL LKGKRVELAD
EIKKVRHVLE LLEEFVQELN KEKT
//
