ID T1G4U3_HELRO Unreviewed; 1064 AA.
AC T1G4U3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=20216091 {ECO:0000313|EnsemblMetazoa:HelroP82615};
GN ORFNames=HELRODRAFT_82615 {ECO:0000313|EMBL:ESO00947.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP82615, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00947.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP82615}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01005284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096864; ESO00947.1; -; Genomic_DNA.
DR RefSeq; XP_009021118.1; XM_009022870.1.
DR AlphaFoldDB; T1G4U3; -.
DR STRING; 6412.T1G4U3; -.
DR EnsemblMetazoa; HelroT82615; HelroP82615; HelroG82615.
DR GeneID; 20216091; -.
DR KEGG; hro:HELRODRAFT_82615; -.
DR CTD; 20216091; -.
DR eggNOG; KOG1023; Eukaryota.
DR HOGENOM; CLU_001072_1_2_1; -.
DR InParanoid; T1G4U3; -.
DR OMA; ILFTTYC; -.
DR OrthoDB; 2877804at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 418..697
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 765..895
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 997..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 121079 MW; A394745A8693B8BD CRC64;
TEFIWQNVSA FIGPEVSCSY EAKLATAWNL PMIGFKCLDS KLTSLNNTFA RTSPSINKVS
KSVIALMKYF EWTHFQAVVD EKEVWKEAIQ SLSELASEHG ITMNKNAYLS EPYYQNARNV
LTKTYTKTRI YIFFGDPEAL IDFVRAMTDL NLGTGEYLVI AVQEEIFEPK KNAEYFKKCR
WKWLESYFEE FKKEQALAFA MTLMLFPRTP NESTKYKTFI KEITVSIYAS HLYDAVLLYA
KALYNVILDG SKPNDGAAII SKIWNSTYES IQGHTIYIDE DGDAEANYTV RRKLQNEDDA
FRIYVNKDAM IHNKVSKSLR PIGHFISKGT EIPDFIYERK INWVGGKVPK SEPKCGFDDS
KCKIQSGWPI ALICLAFGSI FVTGAIFTTR HYLYEQKVAS LLWKIDFKDL LMADLDHDLP
VNDKMRGRFG RLSYLSTDDS YARIASYKSS LVAVKALKKK HIELTREMKR ELLLMKELSH
DNLNRFIGAC IEPFHVCIVT QYCSRGSLKD ILENGDIHLD DVFVASLVFD LIRGMIFLHD
SDIISHGNLN TSNCLVDSRW VLQITDYGLH GLRMGQYPQQ ENQVMWEKLI WKSPEILRDR
TIQPRGTQKG DVYSFGLVLF NIHDRAGPWG QTTLTAKNIV ENVMYPQKNW LCRPDVSEMK
CKDFVSKCIL ECLSEESELR PDFKFIRIKL KPMQEGLSSN IFDNMLAIME KYANTLESLV
DERTYQLAQE KKTTETLLLR MLPKSVAEQL MKGERVQPEH YESVTIYFSD IVGFTTLSAD
STPLEIVNML NDLYTSFDSV IEAFDVYKVE TIGDAYMVAS GLPIRNGNNH AGEIASMSLQ
LLRTIRGFRI RHKPQHTLKL RIGIHSGPVV AGIVGLKMPR YCLFGDTVNT ASRMESSGEA
LKIHCSDQSM LLLKKLGGYD LIARGSICIK GKGRVNTYFL LGEDVSQRRR RMSFEKPELF
YQEHHNQSSL FPVSDDDSLK YGSMSLCPPS FNHSINFDSS PKNVSDDSSS SNQLISNKRP
QQDKSVSLNG VTTTGSSSSN SSSTILLTEN SKVPIVIVTR DFPN
//
