ID T1G5M2_HELRO Unreviewed; 776 AA.
AC T1G5M2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN Name=20216369 {ECO:0000313|EnsemblMetazoa:HelroP84693};
GN ORFNames=HELRODRAFT_84693 {ECO:0000313|EMBL:ESN98219.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP84693, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98219.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP84693}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01005935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01005936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097182; ESN98219.1; -; Genomic_DNA.
DR RefSeq; XP_009023541.1; XM_009025293.1.
DR AlphaFoldDB; T1G5M2; -.
DR STRING; 6412.T1G5M2; -.
DR EnsemblMetazoa; HelroT84693; HelroP84693; HelroG84693.
DR GeneID; 20216369; -.
DR KEGG; hro:HELRODRAFT_84693; -.
DR CTD; 20216369; -.
DR eggNOG; KOG2166; Eukaryota.
DR HOGENOM; CLU_004747_7_1_1; -.
DR InParanoid; T1G5M2; -.
DR OMA; MFKDMTI; -.
DR OrthoDB; 21270at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 380..637
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 776 AA; 90278 MW; C455567FAE9DBCE4 CRC64;
MNANKQPKKD TKMRIRAFPM TMDEKYVNSI WSLLKNAIQE IQKKNNSGLS FEELYRNAYT
MVLHKHGEKL YTGLREVVTD HLVNKVREEV LESLQNNFLQ VLNAAWNDHQ TSMVMIRDIL
MYMDRVYVQQ NNVDNVYNLG LMIFRDQIIR YPPIHQHLRE TLLSMVAKER KGEVVDRGAV
KNGCQMLMVL GIDSRAVYEE DFERPFLVQS AEFYRLESEK FLSENSASVY IKKVEARILE
EQERAVHYLD KSTKEPIVRV VQEELIRKHM RTIVEMPNSG VVHMLKNNKT EDLDCMFRLF
SVVHDGLKTM SDCISAHLRE QGKSLVTEDS NGCNPIIYIQ SLLDLKDRFD HFLHESFSND
RLFKQMISSD FEHFINLNSK SPEYLSLFID DRLRKGVKGM SEQEIETVLD KSMVLFRFLQ
EKDVFERYYK QHLAKRLLLN KSVSDDSEKN MISKLKTECG CQFTSKLEGM FKDMTVSNTI
MEEFRQHVNF TRANMFGMDL CVRVLTTGFW PFQSSTTTCN IPATSRQAFE TFRRFYLGKH
SGRQLSLQAQ HGSADLHAVF HASKRNGSMD ANDDESCSGA VAQGKSGGLR KHILQVSTYQ
MVVLMLFNSR DVWTYEEIKN ETDIPERDLM RSVQSLALGK ITQRVLTKDP KTKEIEPNHS
FTVNDQFTSK LFRVKIQAVT NKSDSEPERV ETRNKVDEDR KHEYPFILGI EVAAVVRIMK
ARKQLQHNVL VAEVTEQLKA RFLPSPVVIK KRIEGLIERE YLSRTPEDRK VYTYVA
//
