ID T1G6D6_HELRO Unreviewed; 1144 AA.
AC T1G6D6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN Name=20216633 {ECO:0000313|EnsemblMetazoa:HelroP86536};
GN ORFNames=HELRODRAFT_86536 {ECO:0000313|EMBL:ESN95628.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP86536, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN95628.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP86536}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01006726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01006727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01006728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01006729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097510; ESN95628.1; -; Genomic_DNA.
DR RefSeq; XP_009026180.1; XM_009027932.1.
DR AlphaFoldDB; T1G6D6; -.
DR STRING; 6412.T1G6D6; -.
DR EnsemblMetazoa; HelroT86536; HelroP86536; HelroG86536.
DR GeneID; 20216633; -.
DR KEGG; hro:HELRODRAFT_86536; -.
DR CTD; 20216633; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_3_2_1; -.
DR InParanoid; T1G6D6; -.
DR OMA; TISETHY; -.
DR OrthoDB; 211054at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF15; DYNEIN AXONEMAL HEAVY CHAIN 8; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 75..214
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 684..832
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 1144 AA; 129582 MW; A90F437FCA06710D CRC64;
MVFTFQVKLH VKSVSDFEWL KQSRFYFDDE EDKTNCIITD VINIYQNEFI GCTERLVITP
LTDRCYITMA QSLGMSMGAA PAGPAGTGKT ETVKDMGKAL GKYVVVFNCS DQMDFRGLGR
IFKGLAQSGS WGCFDEFNRI ELPVLSVAAQ QICIVLMAKK NKKRTFVFSD GDTVSMNPEF
GIFLTMNPGY AGRQELPENL KVMFRTVAMM VPDRMIIIRI KLASNGFLEN VLLSQKFYVL
YKLCEEQLSK QVHYDFGLRN ILSVLRTLGA VKKTSINEQE SFIVMKCLKD LNLSKLVDED
EPLLLSLIDD LFPGIVTQPV SYQSLQAAIS NNLLAYKLIN YPAWNLKILQ LFETQRVRHG
MMTLGPSGAG KTCCIYTLMR SMTDCGQPHK EMRMNPKAIT ASQMFGRLDV ASNDWTDGVF
SSLWRKTLKV KKSESVWLVL DGPVDAIWIE NLNSVLDDTK KLTLANGDRI PMAVNCKIIF
EVHNIDNASP ATVSRNGMVF MSSSCLEWRP ILQGWLLTRS SSESEILLAL FDKIYQDIVN
FGYGNLTKKM DVLQCMEIKQ AIDLLEGLIG SQTDRSTHLT TNHLQKIFIF SLMWSFGNLL
ELDGRVKLQE FMLNHSSKLN YPKLMGEKTI FEYLVDSSGE WLHWSEKVPE YIYPTDYVPD
YASILIPNVD NVRANFLIHT IAKQHKAVLL IGEQGTAKTV MIKGYMSKYN KEEHSHKSIV
FSSATTPNIF QTTIESCVEK RIGATYGPPG GKTMTIFVDD INMPLVNEWG DQPTNEIVRQ
LMEFRGFYNL SKPGEFSSVI DLQLLAAMIH PGGGRNDIPQ RLKRQFSIFN CTLPSIHSMD
KIFRSIALGY FCSERGFSSE VVDFVEDLIS LTRVVWQRTK SKMLPTPAKF HYVFNLRDLS
RIWEGILMVK APQCTSEAII ASLWKHECTR VIADRFVSAE DRKWFENEIS QPIIMDDPIV
LSSMNEPYFV DILKDEPELT GDEPEDFEAG MPRIYEKIPS MDVLQNRLST FMKQYIENIR
GTTLNMVLFK DAMTHIVKVL RIIRTPGGNA LLVGVGGSGK QSTAKLASFI YGYKVFQITL
NRTYNTSNLL EDLKNLMKST GGSGQGFTFV FTDNEIKEES FLDYINNLLS TGEISGLFPR
VSFV
//
