ID T1G751_HELRO Unreviewed; 313 AA.
AC T1G751;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=DUS-like FMN-binding domain-containing protein {ECO:0000259|Pfam:PF01207};
GN Name=20216898 {ECO:0000313|EnsemblMetazoa:HelroP88660};
GN ORFNames=HELRODRAFT_88660 {ECO:0000313|EMBL:ESN93492.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP88660, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN93492.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP88660}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; AMQM01007378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097605; ESN93492.1; -; Genomic_DNA.
DR RefSeq; XP_009028342.1; XM_009030094.1.
DR AlphaFoldDB; T1G751; -.
DR STRING; 6412.T1G751; -.
DR EnsemblMetazoa; HelroT88660; HelroP88660; HelroG88660.
DR GeneID; 20216898; -.
DR KEGG; hro:HELRODRAFT_88660; -.
DR CTD; 20216898; -.
DR eggNOG; KOG2334; Eukaryota.
DR HOGENOM; CLU_013299_3_0_1; -.
DR InParanoid; T1G751; -.
DR OMA; GPIRTNS; -.
DR OrthoDB; 276273at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IBA:GO_Central.
DR GO; GO:0002943; P:tRNA dihydrouridine synthesis; IBA:GO_Central.
DR CDD; cd02801; DUS_like_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035587; DUS-like_FMN-bd.
DR InterPro; IPR018517; tRNA_hU_synthase_CS.
DR PANTHER; PTHR45936; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR PANTHER; PTHR45936:SF1; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR Pfam; PF01207; Dus; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS01136; UPF0034; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 17..264
FT /note="DUS-like FMN-binding"
FT /evidence="ECO:0000259|Pfam:PF01207"
SQ SEQUENCE 313 AA; 35558 MW; 4A48709BC916544E CRC64;
IMNNVNKCRH FYENKVILAP MVRISCLPMR LLALEYGADL VFCEEIIDHK MLQCRQVQNE
LLGTTDFLWS DDSVIFRTCD LERDKVIFQI GTSSADRALK VAKMVEDHVA GIDINMGCPK
EFSIKGGMGA ALMSQPEKFS EILTSLVKNV KKPISCKTRI KSDLEGTLEM MKRIEATGVS
CITIHGRTKE ERPNDENHDD VISHVTCHLT VPVVANGGSS MIKTYKDIEV FKKSTNCSSV
MIGRSAMWNP SIFRNQGCTD DVDVVIRKFL KYAIKYDTFL ACVKYCIQQF MHENLESYKG
RQMLNSTTVR EIW
//
