ID T1G7K8_HELRO Unreviewed; 495 AA.
AC T1G7K8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=20217055 {ECO:0000313|EnsemblMetazoa:HelroP90075};
GN ORFNames=HELRODRAFT_90075 {ECO:0000313|EMBL:ESN91984.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP90075, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN91984.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP90075}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01007876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097680; ESN91984.1; -; Genomic_DNA.
DR RefSeq; XP_009029887.1; XM_009031639.1.
DR AlphaFoldDB; T1G7K8; -.
DR EnsemblMetazoa; HelroT90075; HelroP90075; HelroG90075.
DR GeneID; 20217055; -.
DR KEGG; hro:HELRODRAFT_90075; -.
DR CTD; 20217055; -.
DR eggNOG; KOG1023; Eukaryota.
DR HOGENOM; CLU_001072_11_2_1; -.
DR InParanoid; T1G7K8; -.
DR OrthoDB; 1356373at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF509; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..225
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 296..425
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 233..264
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 495 AA; 56750 MW; 275E94182C52D98A CRC64;
MANIRHQNLN LFLGVCLDLP NSCLMYLYNK FGSLTDLIRE QKIRPNYDNK LSLVLDITSG
MDYLHRSLLK IHGHLSSKNC VIDNRFIASY SFSLENFNSN IKNDLHYKHF SVADALYLAP
ELLQISKGNF LSEQGSPEGD VYAFGIIMQE VIMWDVPYAI ERQNKPISQI LRQVMLTTMR
HPIRPLIPEN LCSDEWLELM KKCLRQQPDR RATFASINFD FKKMLKGKTV HIMDVTLEKL
EKLNEKLQIL VSRRTEELKQ KKAEVEAWIF NILPVGIARA MLKNKTVHPQ EFEEATIYFS
DIVGFDIICQ TGSPAFIVDF LNNVFRHFDL VTDKYDLYKC ETTKDVYMVA SGVPKKIRHH
ASEIATMALD MFTTINKFEI PGTNNNVLQL RIGLHSGPVV AGILGTSLPQ YCIYGDSVNT
ASRMQTSGYA LRIHMSDTTN KLLQATNEFD TMERGKIEVK GKGIMTTHWL LGKRNTDLYV
PDPTLAAARW MHHFK
//
