ID T1G889_HELRO Unreviewed; 345 AA.
AC T1G889;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=20217286 {ECO:0000313|EnsemblMetazoa:HelroP91786};
GN ORFNames=HELRODRAFT_91786 {ECO:0000313|EMBL:ESO10472.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP91786, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10472.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP91786}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class CDC14 subfamily. {ECO:0000256|ARBA:ARBA00007315}.
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DR EMBL; AMQM01008862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01008869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095865; ESO10472.1; -; Genomic_DNA.
DR RefSeq; XP_009011410.1; XM_009013162.1.
DR AlphaFoldDB; T1G889; -.
DR STRING; 6412.T1G889; -.
DR EnsemblMetazoa; HelroT91786; HelroP91786; HelroG91786.
DR GeneID; 20217286; -.
DR KEGG; hro:HELRODRAFT_91786; -.
DR CTD; 20217286; -.
DR eggNOG; KOG1720; Eukaryota.
DR HOGENOM; CLU_017787_0_2_1; -.
DR InParanoid; T1G889; -.
DR OMA; HRANAVC; -.
DR OrthoDB; 9871at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:1902636; C:kinociliary basal body; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IBA:GO_Central.
DR GO; GO:0007096; P:regulation of exit from mitosis; IBA:GO_Central.
DR CDD; cd14499; CDC14_C; 1.
DR CDD; cd17657; CDC14_N; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR044506; CDC14_C.
DR InterPro; IPR029260; DSPn.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR23339:SF27; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF14671; DSPn; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 176..334
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 259..321
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 345 AA; 39289 MW; 446497E22E8CF87D CRC64;
MLVFFIFLHH TDKFYFLTFQ NDKLKSSSEV HYFCTDDQFT YKNFNLDFGP LNLAMICRYC
ILVRKKIESF QATGRKLCHV TSQDSKKRTN AAFLVGCYSV LVAEKSPEET VRCLISQPKV
PIYLPYRDVS LGPSLYNLGL LDCFRALVKS RTLGIFNLTS FNVAEYEHLE KMANGDINWI
IPEKFLALPG PQNKLLANKA GFMSHTPEFY IPYFKQNNVT SVVRLNKDMY PSKKFTDAGI
KHYDMYFPDG TVPPIALVKK FMDVCHKTPG AIAVHCKAGL GRTGTMIGCY MMKYMKFTAA
ESIAWLRMAR PGSVIGMQQV FLNESVSHSA MTITILTNKN LKKLK
//
