ID T1G8V1_HELRO Unreviewed; 652 AA.
AC T1G8V1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN Name=20217498 {ECO:0000313|EnsemblMetazoa:HelroP93299};
GN ORFNames=HELRODRAFT_93299 {ECO:0000313|EMBL:ESO12453.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP93299, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12453.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP93299}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AMQM01000171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12453.1; -; Genomic_DNA.
DR RefSeq; XP_009009173.1; XM_009010925.1.
DR AlphaFoldDB; T1G8V1; -.
DR STRING; 6412.T1G8V1; -.
DR EnsemblMetazoa; HelroT93299; HelroP93299; HelroG93299.
DR GeneID; 20217498; -.
DR KEGG; hro:HELRODRAFT_93299; -.
DR CTD; 20217498; -.
DR eggNOG; KOG1934; Eukaryota.
DR HOGENOM; CLU_002359_4_1_1; -.
DR InParanoid; T1G8V1; -.
DR OMA; RPPDYHE; -.
DR OrthoDB; 2876883at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR PANTHER; PTHR10796:SF92; PATCHED-RELATED, ISOFORM A; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..94
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 523..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 72359 MW; 70AEE9D45B7E2421 CRC64;
MPFLVLGIGV DDMLQLLIEW RKVSATSTQD ERLSNTLRSA AVSITITSLT DLLAFCIGAT
SPFLSVRNFC ACSGLGIFLC YMNQLTFFSG CIVLISRRSK CCQRKKKQIP QESLCLGNSL
NSCDRKSFSA PAVGICETFS KYFSKYYPKI LLHWVGKTIT VIIFVAYVCM SIYGVTRLEE
GLNLEALVPS EHYYRHHAVI DYKFFPNCGI VVTFVIHQPI TYHEVRTQEK VHSFLKSVEA
SDFVVDNSSV SWLEAYNHSL MSKDKPKRKV WNASEFGKKL QTEFLPKNFQ YLADVKFSKH
AKSPWVIEAS RFYVVCHRTN TSEDEKDLML EMRKLASNSS LPMKAFSPNF VFYEHYASIV
KNTLLPVGVT VIGMLFVALV FIPHPIAVTC VIGSMASVVV GMMGFMQLCS LALSAITTMQ
IILGVGICVS FTVRTSHAFM TATGKSRNER VTSALVKVGA SILTGASCSS LSAFALYYGS
SFIFASFFKT MAFALFLGVL HSIVFLPVML SFVGPRRTGK PRLFIPTTAP SSTPSADSNV
DSKEKNYSSC TSKEKLERKL SQESTTSKNS FNTQTVKPLK SSLSNLPRVS SKSLLFSNSK
DDKISAESAN SNDEEACTKN TKQHKVSFKL EDSLKPQTVQ SSELSLCEKN CD
//
